The Generation R Study Biobank: a resource for epidemiological studies in children and their parents

被引：207

作者：

Jaddoe, Vincent W. V. ^{[1
,2
,3
]}

Bakker, Rachel ^{[1
]}

van Duijn, Cock M. ^{[2
]}

van der Heijden, Albert J. ^{[3
]}

Lindemans, Jan ^{[4
]}

Mackenbach, Johan P. ^{[5
]}

Moll, Henriette A. ^{[3
]}

Steegers, Eric A. P. ^{[6
]}

Tiemeier, Henning ^{[7
]}

Uitterlinden, Andre G. ^{[2
,4
,8
]}

Verhulst, Frank C. ^{[7
]}

Hofman, Albert ^{[2
]}

机构：

[1] Erasmus MC, GEnerat R Study Grp, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[3] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Paediat, Rotterdam, Netherlands

[4] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands

[5] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands

[6] Erasmus MC, Dept Obstet & Gynaecol, Rotterdam, Netherlands

[7] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands

[8] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2007年 / 22卷 / 12期

关键词：

cohort study; Biobank; child; parents;

D O I：

10.1007/s10654-007-9209-z

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have been conducted for collecting biological specimens including DNA, blood for phenotypes and urine samples. In this paper, the collection, processing and storage of these biological specimens are described. Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.

引用

页码：917 / 923

页数：7

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