A new technetium-99m labeled isonitrile complex 99mTc-TMCHI as a potential blood pool imaging agent

被引：2

作者：

Zhang, XZ ^{[1
]}

Wang, XB ^{[1
]}

Zhou, JM ^{[1
]}

机构：

[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

来源：

APPLIED RADIATION AND ISOTOPES | 2003年 / 59卷 / 04期

关键词：

Tc-99m-TMCHI; blood pool agent; isonitrile; biodistribution; 3,3,5-trimethyl cyclohexylisonitrile;

D O I：

10.1016/S0969-8043(03)00169-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new isonitrile ligand 3,3,5-trimethyl cyclohexylisonitrile (TMCHI) and its copper salt [Cu(TMCHI)(4)BF4] were synthesized and characterized by IR and elemental analysis. Tc-99m-TMCHI is prepared by direct labeling method with high RCP. In vitro protein binding in albumin, blood retention and biodistribution of Tc-99m-TMCHI in mice indicated that it is mainly accumulated and maintained in blood with a high protein binding rate and low washout rate. The target/non-target ratios in mice are excellent and suggest its use as a cardiac blood pool agent. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：231 / 235

页数：5

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