Concise and practical synthesis of latrunculin A by ring-closing enyne-yne metathesis

被引：181
|
作者：
Fürstner, A [1 ]
Turet, L [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 22期
关键词：
alkynes; cross-coupling; macrocycles; metathesis; natural products;
D O I：
10.1002/anie.200500390
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne-yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3462 / 3466
页数：5
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