Concise and practical synthesis of latrunculin A by ring-closing enyne-yne metathesis

被引：181

作者：

Fürstner, A ^{[1
]}

Turet, L ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 22期

关键词：

alkynes; cross-coupling; macrocycles; metathesis; natural products;

D O I：

10.1002/anie.200500390

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne-yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3462 / 3466

页数：5

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