Concise and practical synthesis of latrunculin A by ring-closing enyne-yne metathesis

被引：182
作者：
Fürstner, A [1 ]
Turet, L [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 22期
关键词：
alkynes; cross-coupling; macrocycles; metathesis; natural products;
D O I：
10.1002/anie.200500390
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne-yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：3462 / 3466
页数：5
相关论文
共 55 条
[1]  
[Anonymous], 2002, ANGEW CHEM
[2]  
[Anonymous], 2002, ANGEW CHEM
[3]  
[Anonymous], ANGEW CHEM
[4]  
BLASBERGER D, 1989, LIEBIGS ANN CHEM, P1171
[5]   Enyne metathesis (enyne bond reorganization) [J].
Diver, ST ;
Giessert, AJ .
CHEMICAL REVIEWS, 2004, 104 (03) :1317-1382
[6]  
Fürstner A, 2002, ANGEW CHEM INT EDIT, V41, P609
[7]   Advances in iron catalyzed cross coupling reactions [J].
Fürstner, A ;
Martin, R .
CHEMISTRY LETTERS, 2005, 34 (05) :624-629
[8]   Iron-catalyzed cross-coupling reactions [J].
Fürstner, A ;
Leitner, A ;
Méndez, M ;
Krause, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (46) :13856-13863
[9]   A catalytic approach to (R)-(+)-muscopyridine with integrated "self-clearance" [J].
Fürstner, A ;
Leitner, A .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (03) :308-+
[10]  
Fürstner A, 2002, CHEM-EUR J, V8, P1856, DOI 10.1002/1521-3765(20020415)8:8<1856::AID-CHEM1856>3.0.CO
123456