Similar familial risk in multiple sclerosis subgroups

被引：2
作者：
Song, Jie [2 ]
Karrenbauer, Virginija [3 ]
Manouchehrinia, Ali [3 ]
Almqvist, Catarina [2 ,4 ]
Hillert, Jan [3 ]
Westerlind, Helga [1 ,5 ]
机构：
[1] Karolinska Inst, Inst Environm Med IMM, Box 210, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[3] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
[4] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Lung & Allergy Unit, Stockholm, Sweden
[5] Karolinska Inst, Dept Med Solna, Rheumatol Unit, Stockholm, Sweden
来源：
MULTIPLE SCLEROSIS JOURNAL | 2017年 / 23卷 / 13期
基金：
瑞典研究理事会;
关键词：
Multiple sclerosis; oligoclonal band negative; oligoclonal band positive; familial risks; epidemiology; genetics; QUALITY-OF-LIFE; CIGARETTE-SMOKING; NARCOMS-REGISTRY; PERFORMANCE-SCALES; DISABILITY; PROGRESSION; VALIDATION; PROGNOSIS; CESSATION; VALIDITY;
D O I：
10.1177/1352458516684214
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: A subgroup of patients diagnosed with multiple sclerosis (MS) present with no oligoclonal bands (OCB) in the cerebrospinal fluid (CSF). Several studies report different clinical characteristics and genetic associations between the two groups. Objective: To investigate whether the OCB negative subgroup has a distinct etiology from band positive MS. Methods: Using nationwide registers to estimate familial risks, which reflect the genetic contribution of a disease. Results: Odds ratios of MS were similar for relatives to band positive and negative patients. Conclusion: From the perspective of familial liability, MS without OCB is etiologically closely related to the dominant subgroup of OCB positive MS.
引用
收藏
页码：1782 / 1785
页数：4
相关论文
共 33 条
[1]   Gender differences in health-related quality of life in multiple sclerosis [J].
Casetta, Ilaria ;
Riise, Trond ;
Nortvedt, Monica Wamme ;
Economou, Nicola Tiberio ;
De Gennaro, Riccardo ;
Fazio, Patrik ;
Cesnik, Edward ;
Govoni, Vittorio ;
Granieri, Enrico .
MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (11) :1339-1346
[2]   The Patient-Reported Outcomes Measurement Information System (PROMIS) Progress of an NIH roadmap cooperative group during its first two years [J].
Cella, David ;
Yount, Susan ;
Rothrock, Nan ;
Gershon, Richard ;
Cook, Karon ;
Reeve, Bryce ;
Ader, Deborah ;
Fries, James F. ;
Bruce, Bonnie ;
Rose, Mattias .
MEDICAL CARE, 2007, 45 (05) :S3-S11
[3]   Bifactor structure of clinical disability in relapsing multiple sclerosis [J].
Chamot, Eric ;
Kister, Ilya ;
Cutter, Garry R. .
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2014, 3 (02) :176-185
[4]   Item response theory-based measure of global disability in multiple sclerosis derived from the Performance Scales and related items [J].
Chamot, Eric ;
Kister, Ilya ;
Cutter, Gary R. .
BMC NEUROLOGY, 2014, 14
[5]   Individual factors enhance poor health-related quality of life outcome in multiple sclerosis patients. Significance of predictive determinants [J].
Cioncoloni, David ;
Innocenti, Iglis ;
Bartalini, Sabina ;
Santarnecchi, Emiliano ;
Rossi, Simone ;
Rossi, Alessandro ;
Ulivelli, Monica .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 345 (1-2) :213-219
[6]   Relapses and progression of disability in multiple sclerosis. [J].
Confavreux, C ;
Vukusic, S ;
Moreau, T ;
Adeleine, P .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (20) :1430-1438
[7]   Smoking worsens multiple sclerosis prognosis: Two different pathways are involved [J].
Correale, Jorge ;
Farez, Mauricio F. .
JOURNAL OF NEUROIMMUNOLOGY, 2015, 281 :23-34
[8]   Clinical appropriateness: a key factor in outcome measure selection: the 36 item short form health survey in multiple sclerosis [J].
Freeman, J ;
Hobart, JC ;
Langdon, DW ;
Thompson, AJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 68 (02) :150-156
[9]   Smoking rates and smoking cessation among individuals with multiple sclerosis [J].
Friend, K. B. ;
Mernoff, S. T. ;
Block, P. ;
Reeve, G. .
DISABILITY AND REHABILITATION, 2006, 28 (18) :1135-1141
[10]   Quality of Life and Smoking [J].
Goldenberg, Matthew ;
Danovitch, Itai ;
IsHak, Waguih William .
AMERICAN JOURNAL ON ADDICTIONS, 2014, 23 (06) :540-562
1234