P-Rex1, a Guanine Exchange Factor that Is Overexpressed in Breast Cancer, Is a Convergence Node for ErbB and CXCR4 Signaling

被引：6

作者：

Hynes, Nancy E. ^{[1
]}

Gattelli, Albana ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

MOLECULAR CELL | 2011年 / 41卷 / 01期

关键词：

GROWTH-FACTOR RECEPTOR; RAC;

D O I：

10.1016/j.molcel.2010.12.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent issue of Molecular Cell, Kazanietz and colleagues (Sosa et al., 2010) show that P-Rex1, a Rac1 GEF, is overexpressed in ER+ and/or ErbB2+ breast cancers, suggesting that P-Rex1 might be a convergence node downstream of these receptors and an attractive therapeutic target.

引用

页码：5 / 7

页数：3

共 10 条

[1] Management of breast cancer with targeted agents: importance of heterogenicity [J].

Di Cosimo, Serena ;

Baselga, Jose .

NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (03) :139-147

[2] ERBB receptors and cancer: The complexity of targeted inhibitors [J].

Hynes, NE ;

Lane, HA .

NATURE REVIEWS CANCER, 2005, 5 (05) :341-354

[3] P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer [J].

Montero, J. C. ;

Seoane, S. ;

Ocana, A. ;

Pandiella, A. .

ONCOGENE, 2011, 30 (09) :1059-1071

[4] 17β-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation:: reversal by gefitinib pretreatment [J].

Pattarozzi, Alessandra ;

Gatti, Monica ;

Barbieri, Federica ;

Wuerth, Roberto ;

Porcile, Carola ;

Lunardi, Gianluigi ;

Ratto, Alessandra ;

Favoni, Roberto ;

Bajetto, Adriana ;

Ferrari, Angelo ;

Florio, Tullio .

MOLECULAR PHARMACOLOGY, 2008, 73 (01) :191-202

[5] Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis [J].

Qin, J. ;

Xie, Y. ;

Wang, B. ;

Hoshino, M. ;

Wolff, D. W. ;

Zhao, J. ;

Scofield, M. A. ;

Dowd, F. J. ;

Lin, M-F ;

Tu, Y. .

ONCOGENE, 2009, 28 (16) :1853-1863

[6] 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial [J].

Smith, Ian ;

Procter, Marion ;

D Gelber, Richard ;

Guillaume, Sebastien ;

Feyereislova, Andrea ;

Dowsett, Mitch ;

Goldhirsch, Aron ;

Untch, Michael ;

Mariani, Gabriella ;

Baselga, Jose ;

Kaufmann, Manfred ;

Cameron, David ;

Bell, Richard ;

Bergh, Jonas ;

Coleman, Robert ;

Wardley, Andrew ;

Harbeck, Nadia ;

Lopez, Roberto I. ;

Mallmann, Peter ;

Gelmon, Karen ;

Wilcken, Nicholas ;

Wist, Erik ;

Sanchez Rovira, Pedro ;

Piccart-Gebhart, Martine .

LANCET, 2007, 369 (9555) :29-36

[7] Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer [J].

Sosa, Maria Soledad ;

Lopez-Haber, Cynthia ;

Yang, Chengfeng ;

Wang, HongBin ;

Lemmon, Mark A. ;

Busillo, John M. ;

Luo, Jiansong ;

Benovic, Jeffrey L. ;

Klein-Szanto, Andres ;

Yagi, Hiroshi ;

Gutkind, J. Silvio ;

Parsons, Ramon E. ;

Kazanietz, Marcelo G. .

MOLECULAR CELL, 2010, 40 (06) :877-892

[8] Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? [J].

Vigil, Dominico ;

Cherfils, Jacqueline ;

Rossman, Kent L. ;

Der, Channing J. .

NATURE REVIEWS CANCER, 2010, 10 (12) :842-857

[9] P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac [J].

Welch, HCE ;

Coadwell, WJ ;

Ellson, CD ;

Ferguson, GJ ;

Andrews, SR ;

Erdjument-Bromage, H ;

Tempst, P ;

Hawkins, PT ;

Stephens, LR .

CELL, 2002, 108 (06) :809-821

[10] Essential role for Rac in heregulin β1 mitogenic signaling:: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4 [J].

Yang, CF ;

Liu, Y ;

Lemmon, MA ;

Kazanietz, MG .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (03) :831-842

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