Monitoring hepatocellular carcinoma metastasis by in-vivo flow cytometer

被引：0

作者：

Li, Yan ^{[1
,2
]}

Guo, Jin ^{[1
,3
]}

Liu, Guangda ^{[1
]}

Wang, Chen ^{[4
]}

Gu, Zhengqin ^{[5
]}

Wei, Xunbin ^{[1
,2
]}

机构：

[1] Fudan Univ, Inst Biomed Sci, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[3] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China

[4] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai 200093, Peoples R China

[5] Jiaotong Univ, Xinhua Hosp, Dept Urol, Shanghai 200092, Peoples R China

来源：

BIOPHOTONICS AND IMMUNE RESPONSES V | 2010年 / 7565卷

基金：

美国国家科学基金会;

关键词：

in-vivo flow cytometer; in-vivo fluorescence imaging; cancer metastasis; liver cancer; circulating tumor cells; near-infrared; confocal imaging; APOPTOSIS; LEUKEMIA; INDUCTION; MARKERS; CELLS;

D O I：

10.1117/12.843459

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A recently developed "in vivo flow cytometer" and optical imaging are used to assess liver tumor cell spreading and the circulation kinetics of liver tumor cells. The in vivo flow cytometer has the capability to detect and quantify the number and flow characteristics of fluorescently labeled cells in vivo continuously. The depletion rate of circulating tumor cells provides insights in early cancer metastasis. It is useful to understand the molecular mechanisms of liver tumor metastasis. A real-time quantitative monitoring of circulating liver tumor cells by the in vivo flow cytometer will help assess the effectiveness of the potential therapeutic interventions.

引用

页数：6

共 27 条

[21] Two-color, double-slit in vivo flow cytometer [J].

Novak, J. ;

Puoris'haag, M. .

OPTICS LETTERS, 2007, 32 (20) :2993-2995

[22] In vivo flow cytometer for real-time detection and quantification of circulating cells [J].

Novak, J ;

Georgakoudi, I ;

Wei, X ;

Prossin, A ;

Lin, CP .

OPTICS LETTERS, 2004, 29 (01) :77-79

[23] Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate [J].

Ntziachristos, V ;

Schellenberger, EA ;

Ripoll, J ;

Yessayan, D ;

Graves, E ;

Bogdanov, A ;

Josephson, L ;

Weissleder, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (33) :12294-12299

[24] Expression of apoptosis markers on peripheral blood lymphocytes from patients with cutaneous T-cell lymphoma during extracorporeal photochemotherapy [J].

Osella-Abate, S ;

Zaccagna, A ;

Savoia, P ;

Quaglino, P ;

Salomone, B ;

Bernengo, MG .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 44 (01) :40-47

[25] Dysregulation of apoptosis in cancer [J].

Reed, JC .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (09) :2941-2953

[26] In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment [J].

Sipkins, DA ;

Wei, XB ;

Wu, JW ;

Runnels, JM ;

Côté, D ;

Means, TK ;

Luster, AD ;

Scadden, DT ;

Lin, CP .

NATURE, 2005, 435 (7044) :969-973

[27] Quantitative two-photon flow cytometry -: in vitro and in vivo [J].

Zhong, Cheng Frank ;

Tkaczyk, Eric R. ;

Thomas, Thommey ;

Ye, Jing Yong ;

Myc, Andrzej ;

Bielinska, Anna U. ;

Cao, Zhengyi ;

Majoros, Istvan ;

Keszler, Balazs ;

Baker, James R., Jr. ;

Norris, Theodore B. .

JOURNAL OF BIOMEDICAL OPTICS, 2008, 13 (03)

← 1 2 3 →