Monitoring hepatocellular carcinoma metastasis by in-vivo flow cytometer

被引：0
作者：
Li, Yan [1 ,2 ]
Guo, Jin [1 ,3 ]
Liu, Guangda [1 ]
Wang, Chen [4 ]
Gu, Zhengqin [5 ]
Wei, Xunbin [1 ,2 ]
机构：
[1] Fudan Univ, Inst Biomed Sci, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[3] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China
[4] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai 200093, Peoples R China
[5] Jiaotong Univ, Xinhua Hosp, Dept Urol, Shanghai 200092, Peoples R China
来源：
BIOPHOTONICS AND IMMUNE RESPONSES V | 2010年 / 7565卷
基金：
美国国家科学基金会;
关键词：
in-vivo flow cytometer; in-vivo fluorescence imaging; cancer metastasis; liver cancer; circulating tumor cells; near-infrared; confocal imaging; APOPTOSIS; LEUKEMIA; INDUCTION; MARKERS; CELLS;
D O I：
10.1117/12.843459
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A recently developed "in vivo flow cytometer" and optical imaging are used to assess liver tumor cell spreading and the circulation kinetics of liver tumor cells. The in vivo flow cytometer has the capability to detect and quantify the number and flow characteristics of fluorescently labeled cells in vivo continuously. The depletion rate of circulating tumor cells provides insights in early cancer metastasis. It is useful to understand the molecular mechanisms of liver tumor metastasis. A real-time quantitative monitoring of circulating liver tumor cells by the in vivo flow cytometer will help assess the effectiveness of the potential therapeutic interventions.
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页数：6
相关论文
共 27 条
  • [1] Aotake T, 1999, CLIN CANCER RES, V5, P135
  • [2] Bedner E, 1999, CYTOMETRY, V36, P77, DOI 10.1002/(SICI)1097-0320(19990501)36:1<77::AID-CYTO10>3.3.CO
  • [3] 2-6
  • [4] Blankenberg FG, 2001, J NUCL MED, V42, P309
  • [5] Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes
    Durrieu, F
    Belloc, F
    Lacoste, L
    Dumain, P
    Chabrol, J
    Dachary-Prigent, J
    Morjani, H
    Boisseau, MR
    Reiffers, J
    Bernard, P
    Lacombe, F
    [J]. EXPERIMENTAL CELL RESEARCH, 1998, 240 (02) : 165 - 175
  • [6] Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (TOMUDEX) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia
    Ek, O
    Reaman, GH
    Crankshaw, DL
    Chelstrom, LM
    Myers, DE
    Uckun, FM
    [J]. LEUKEMIA & LYMPHOMA, 1998, 28 (5-6) : 509 - 514
  • [7] Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the Anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase
    Ek, O
    Gaynon, P
    Zeren, T
    Chelstrom, LM
    Myers, DE
    Uckun, FM
    [J]. LEUKEMIA & LYMPHOMA, 1998, 31 (1-2) : 143 - 149
  • [8] Apoptosis in human disease: A new skin for the old ceremony?
    Fadeel, B
    Orrenius, S
    Zhivotovsky, B
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 266 (03) : 699 - 717
  • [9] A method for rapid gain-of-function studies in the mouse embryonic nervous system
    Gaiano, N
    Kohtz, JD
    Turnbull, DH
    Fishell, G
    [J]. NATURE NEUROSCIENCE, 1999, 2 (09) : 812 - 819
  • [10] Radial glial identity is promoted by Notch1 signaling in the murine forebrain
    Gaiano, N
    Nye, JS
    Fishell, G
    [J]. NEURON, 2000, 26 (02) : 395 - 404
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