New insights into oncogenic stress

被引：31

作者：

Haigis, Kevin M. ^{[1
,2
,3
]}

Sweet-Cordero, Alejandro ^{[4
]}

机构：

[1] Massachusetts Gen Hosp, Mol Pathol Unit, Charlestown, MA USA

[2] Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA USA

[3] Harvard Univ, Dept Pathol, Sch Med, Charlestown, MA USA

[4] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

来源：

NATURE GENETICS | 2011年 / 43卷 / 03期

关键词：

DNA-DAMAGE RESPONSE; TUMOR SUPPRESSION; P53; APOPTOSIS; JNK;

D O I：

10.1038/ng0311-177

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

xpression of oncogenes in otherwise normal cells often leads to the activation of anti-oncogenic pathways through a poorly understood process described as 'oncogenic stress'. A new study implicates the Jnk pathway signaling in the activation of p53 in response to both K-Ras and Neu oncogene expression.

引用

页码：177 / 178

页数：2

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