Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family

被引:10
作者
Agnello, D
Meazza, C
Rowan, CG
Villa, P
Ghezzi, P
Senaldi, G
机构
[1] Amgen Inc, Amgen Ctr, Thousand Oaks, CA 91320 USA
[2] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[3] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
关键词
corticosterone; interleukin-1; leukemia inhibitory factor; peripheral blood cells; tumor necrosis factor;
D O I
10.1152/ajpregu.1998.275.3.R913
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To investigate if leptin shares in vivo activities with interleukin (IL)-6 family cytokines, it was tested in normal mice for the ability, after a single injection, to induce the acute-phase protein serum amyloid A, to potentiate the induction by IL-1 of serum corticosterone and IL-6, and to inhibit the induction by lipopolysaccharide of serum tumor necrosis factor and, after seven daily injections, to cause body weight loss and to change peripheral blood cell counts. At a 0.5 mg/kg dose, leptin caused body weight loss but did not show any of the other activities above. At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity. In addition to causing body weight loss, leptin shows only some of the in vivo activities typical of IL-6 family cytokines and only if used at a dose that exceeds the one sufficient to affect body weight. In vivo, leptin seems to chiefly control body weight and not inflammatory or hematopoietic processes.
引用
收藏
页码:R913 / R919
页数:7
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