Iron oxide nanoparticles for therapeutic applications

被引：100

作者：

Alphandery, Edouard ^{[1
,2
,3
]}

机构：

[1] Sorbonne Univ, Museum Natl Hist Nat, IMPMC, CNRS,IRD,UMR 7590, Pl Jussieu, F-75005 Paris, France

[2] Nanobacterie SARL, 36 Blvd Flandrin, F-75116 Paris, France

[3] UZH Univ Zurich, Inst Anat, Winterthurerstr 190, CH-8057 Zurich, Switzerland

来源：

DRUG DISCOVERY TODAY | 2020年 / 25卷 / 01期

关键词：

MAGNETIC NANOPARTICLES; DRUG-DELIVERY; CANCER; HYPERTHERMIA; RELEASE; CELLS; NANOCOMPOSITES; CHEMOTHERAPY; DOXORUBICIN; GENERATION;

D O I：

10.1016/j.drudis.2019.09.020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In nanomedicine, iron oxide nanoparticles are at an advanced stage, being commercialized for cancer treatment and iron-deficiency anemia treatment. Their therapeutic efficacy comes from their ability to target a tissue, activate a drug, locally produce a temperature increase following (or not) the application of an external source of energy, modify genes or activate various biological materials, or replace diseased cells by stem cells. Owing to these various mechanisms of action, they can potentially be used for treating a whole range of different diseases, making them more appealing than conventional drugs that target a more limited number of indications.

引用

收藏

页码：141 / 149

页数：9

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