Novel antifouling oligo(ethylene glycol) methacrylate particles via surfactant-free emulsion polymerization

被引：7

作者：

Buyukserin, Fatih ^{[1
]}

Camli, Sevket Tolga ^{[1
]}

Yavuz, Mustafa Selman ^{[1
]}

Budak, Gurer Guven ^{[1
]}

机构：

[1] Gazi Univ, Nanomed & Adv Technol Res Ctr, TR-06830 Ankara, Turkey

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2011年 / 355卷 / 01期

关键词：

Poly(ethylene glycol) ethyl ether methacrylate; Cross-linked; Surfactant-free emulsion polymerization; Antifouling; Albumin adsorption; BOVINE SERUM-ALBUMIN; POLY(ETHYLENE GLYCOL); SILICA NANOPARTICLES; GENE DELIVERY; CROSS-LINKER; HUMAN PLASMA; ADSORPTION; PH; COPOLYMERIZATION; MICROBEADS;

D O I：

10.1016/j.jcis.2010.11.081

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The use of particle formulations with antifouling surface properties attracts increasing interest in several biotechnological applications. Majority of these studies utilize a poly(ethylene glycol) coating to render the corresponding surface nonrecognizable to biological macromolecules. Herein, we report a simple way to prepare novel antifouling colloids composed of oligo(ethylene glycol) backbones via surfactant-free emulsion polymerization. Monodisperse cross-linked poly(ethylene glycol) ethyl ether methacrylate particles were characterized by dynamic light scattering and transmission electron microscopy. The effects of monomer, cross-linker and initiator on particle characteristics were investigated. More importantly, a prominent blockage of bovine serum albumin adsorption was obtained for the poly(ethylene glycol)-based sub-micron (similar to 200 nm) particles when compared with similar-sized poly(methyl methacrylate) counterparts. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：76 / 80

页数：5

共 53 条

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