Novel antifouling oligo(ethylene glycol) methacrylate particles via surfactant-free emulsion polymerization

被引：7
作者：
Buyukserin, Fatih [1 ]
Camli, Sevket Tolga [1 ]
Yavuz, Mustafa Selman [1 ]
Budak, Gurer Guven [1 ]
机构：
[1] Gazi Univ, Nanomed & Adv Technol Res Ctr, TR-06830 Ankara, Turkey
来源：
JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2011年 / 355卷 / 01期
关键词：
Poly(ethylene glycol) ethyl ether methacrylate; Cross-linked; Surfactant-free emulsion polymerization; Antifouling; Albumin adsorption; BOVINE SERUM-ALBUMIN; POLY(ETHYLENE GLYCOL); SILICA NANOPARTICLES; GENE DELIVERY; CROSS-LINKER; HUMAN PLASMA; ADSORPTION; PH; COPOLYMERIZATION; MICROBEADS;
D O I：
10.1016/j.jcis.2010.11.081
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The use of particle formulations with antifouling surface properties attracts increasing interest in several biotechnological applications. Majority of these studies utilize a poly(ethylene glycol) coating to render the corresponding surface nonrecognizable to biological macromolecules. Herein, we report a simple way to prepare novel antifouling colloids composed of oligo(ethylene glycol) backbones via surfactant-free emulsion polymerization. Monodisperse cross-linked poly(ethylene glycol) ethyl ether methacrylate particles were characterized by dynamic light scattering and transmission electron microscopy. The effects of monomer, cross-linker and initiator on particle characteristics were investigated. More importantly, a prominent blockage of bovine serum albumin adsorption was obtained for the poly(ethylene glycol)-based sub-micron (similar to 200 nm) particles when compared with similar-sized poly(methyl methacrylate) counterparts. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：76 / 80
页数：5
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