FGF/FGFR signaling pathway involved resistance in various cancer types

被引：84
|
作者：
Zhou, Yangyang [1 ,2 ]
Wu, Chengyu [1 ,2 ]
Lu, Guangrong [2 ,3 ]
Hu, Zijing [4 ]
Chen, Qiuxiang [5 ]
Du, Xiaojing [6 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China
[3] Wenzhou Med, Affiliated Hosp 2, Dept Gastroenterol, Wenzhou 325000, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Coll Pharmaceut Sci, Wenzhou 325000, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Affiliated Hosp 1, Dept Ultrason Imaging, South Baixiang, Wenzhou 325035, Zhejiang, Peoples R China
[6] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, South Baixiang, Wenzhou 325035, Zhejiang, Peoples R China
来源：
JOURNAL OF CANCER | 2020年 / 11卷 / 08期
关键词：
FGF/FGFR; resistance; oncotherapy; FGF/FGFR inhibitors; FIBROBLAST-GROWTH-FACTOR; CELL LUNG-CANCER; GASTROINTESTINAL STROMAL TUMOR; ACQUIRED-RESISTANCE; DRUG-RESISTANCE; INHIBITOR RESISTANCE; GATEKEEPER MUTATION; ESCAPE MECHANISM; KINASE; ACTIVATION;
D O I：
10.7150/jca.40531
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we dicussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.
引用
收藏
页码：2000 / 2007
页数：8
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