FGF/FGFR signaling pathway involved resistance in various cancer types

被引：84
|
作者：
Zhou, Yangyang [1 ,2 ]
Wu, Chengyu [1 ,2 ]
Lu, Guangrong [2 ,3 ]
Hu, Zijing [4 ]
Chen, Qiuxiang [5 ]
Du, Xiaojing [6 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China
[3] Wenzhou Med, Affiliated Hosp 2, Dept Gastroenterol, Wenzhou 325000, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Coll Pharmaceut Sci, Wenzhou 325000, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Affiliated Hosp 1, Dept Ultrason Imaging, South Baixiang, Wenzhou 325035, Zhejiang, Peoples R China
[6] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, South Baixiang, Wenzhou 325035, Zhejiang, Peoples R China
来源：
JOURNAL OF CANCER | 2020年 / 11卷 / 08期
关键词：
FGF/FGFR; resistance; oncotherapy; FGF/FGFR inhibitors; FIBROBLAST-GROWTH-FACTOR; CELL LUNG-CANCER; GASTROINTESTINAL STROMAL TUMOR; ACQUIRED-RESISTANCE; DRUG-RESISTANCE; INHIBITOR RESISTANCE; GATEKEEPER MUTATION; ESCAPE MECHANISM; KINASE; ACTIVATION;
D O I：
10.7150/jca.40531
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we dicussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.
引用
收藏
页码：2000 / 2007
页数：8
相关论文
共 50 条
  • [31] FGFR4 provides the conduit to facilitate FGF19 signaling in breast cancer progression
    Zhao, Xiangdong
    Xu, Faliang
    Dominguez, Nestor P.
    Xiong, Yuanping
    Xiong, Zhongxun
    Peng, Hong
    Shay, Chloe
    Teng, Yong
    MOLECULAR CARCINOGENESIS, 2018, 57 (11) : 1616 - 1625
  • [32] Overcoming drug resistance of cancer cells by targeting the FGF1/FGFR1 axis with honokiol or FGF ligand trap
    Szymczyk, Jakub
    Sochacka, Martyna
    Biadun, Martyna
    Sluzalska, Katarzyna Dominika
    Witkowska, Danuta
    Zakrzewska, Malgorzata
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [33] Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor
    Lee, Suk-Young
    Na, Yoo Jin
    Jeong, Yoon A.
    Kim, Jung Lim
    Oh, Sang Cheul
    Lee, Dae-Hee
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2018, 102 : 128 - 137
  • [34] Notch Signaling Pathway and Endocrine Resistance in Breast Cancer
    Bai, Jing-Wen
    Wei, Min
    Li, Ji-Wei
    Zhang, Guo-Jun
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [35] Regulation of metabolism by a neuroendocrine FGF signaling pathway
    David J Mangelsdorf
    Steven A Kliewer
    Cancer & Metabolism, 2 (Suppl 1)
  • [36] FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage
    Okada, Takeshi
    Enkhjargal, Budbazar
    Travis, Zachary D.
    Ocak, Umut
    Tang, Jiping
    Suzuki, Hidenori
    Zhang, John H.
    MOLECULAR NEUROBIOLOGY, 2019, 56 (12) : 8203 - 8219
  • [37] INTRACELLULAR SIGNALING PATHWAYS INVOLVED IN MESODERM INDUCTION BY FGF
    GILLESPIE, LL
    PATERNO, GD
    MAHADEVAN, LC
    SLACK, JMW
    MECHANISMS OF DEVELOPMENT, 1992, 38 (02) : 99 - 108
  • [38] Tephrosin Suppresses the Chemoresistance of Paclitaxel-Resistant Ovarian Cancer via Inhibition of FGFR1 Signaling Pathway
    Kim, Hee Su
    Bae, Sowon
    Lim, Ye Jin
    So, Kyeong A.
    Kim, Tae Jin
    Bae, Seunghee
    Lee, Jae Ho
    BIOMEDICINES, 2023, 11 (12)
  • [39] FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention
    Wang, Yijun
    Liu, Danfei
    Zhang, Tongyue
    Xia, Limin
    CANCERS, 2021, 13 (06) : 1 - 22
  • [40] Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
    Gedaj, Aleksandra
    Gregorczyk, Paulina
    Zukowska, Dominika
    Chorazewska, Aleksandra
    Ciura, Krzysztof
    Kalka, Marta
    Porebska, Natalia
    Opalinski, Lukasz
    CYTOKINE & GROWTH FACTOR REVIEWS, 2024, 77 : 39 - 55
12345