Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America

被引:9
作者
Conder, GA [1 ]
Rooney, KA [1 ]
Illyes, EF [1 ]
Keller, DS [1 ]
Meinert, TR [1 ]
Logan, NB [1 ]
机构
[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA
关键词
doramectin; pour-on; cattle nematode; endectocide; efficacy;
D O I
10.1016/S0304-4017(98)00110-1
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Seven studies were conducted under field conditions in North America to evaluate the therapeutic efficacy of doramectin in a pour-on formulation at a dosage of 500 mu g/kg (1 ml/10 kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Cooperia, and Oesophagostomum. In each study, 40 to 100 cattle were randomly allocated to a saline- or doramectin-treated group in a tiered manner based on Day -7 bodyweight. On Day 0, the cattle received either saline or doramectin topically, according to their treatment group. Weather and safety observations were made following treatment. No adverse reaction to treatment was observed at any time during these studies. Fecal egg count (FEC) determinations were carried out on each animal on Days -7, 0, 7, 14, and 21. Reductions in FEC for the doramectin-treated animals compared to saline-treated cattle were greater than or equal to 96.0% by Day -7 and greater than or equal to 99.0% on Days 14 and 21 for each study. Across all studies regardless of weather conditions, the reduction by Day 21 for the doramectin-treated animals compared to saline controls was 99.7% (p less than or equal to 0.0001) and compared to pretreatment levels in doramectin-treated cattle was 99.9% (p less than or equal to 0.0001). Doramectin pour-on should provide a useful new treatment for controlling nematode parasites of cattle. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:259 / 265
页数:7
相关论文
共 50 条
[41]   Homeopathic treatments efficacy against gastrointestinal nematodes in cattle from the Ecuadorian low tropics [J].
Pacheco-Merelo, Gabriela ;
Montes-Zambrano, Victor ;
Alvarado-Alvarez, Hugo ;
Angulo-Cubillan, Francisco ;
Fonseca-Restrepo, Carolina .
REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS, 2023, 33 (01) :8-8
[42]   Anthelmintic efficacy of an oral formulation of Aurixazol against gastrointestinal nematodes of naturally and experimentally infected sheep [J].
Sakamoto, Claudio Alessandro M. ;
Zanetti Lopes, Welber Daniel ;
Buzzulini, Carolina ;
Cruz, Breno Cayeiro ;
Felippelli, Gustavo ;
Araujo de Lima, Roberto Cesar ;
dos Santos, Thais Rabelo ;
Santana, Luis Fernando ;
de Mendonca, Rafael Paranhos ;
Soares, Vando Edesio ;
Henrique, Carlos Henrique ;
da Costa, Alvimar Jose .
VETERINARY PARASITOLOGY, 2013, 198 (3-4) :336-344
[43]   Anthelmintic efficacy and pharmacokinetics of pour-on eprinomectin (1 mg/kg bodyweight) against gastrointestinal and pulmonary nematode infections in goats [J].
Hamel, Dietmar ;
Visser, Martin ;
Kellermann, Michael ;
Kvaternick, Valerie ;
Rehbein, Steffen .
SMALL RUMINANT RESEARCH, 2015, 127 :74-79
[44]   Seasonal differences in the efficacy of pour-on formulations of triclabendazole and ivermectin or abamectin against late immature liver fluke (Fasciola hepatica) in cattle [J].
Sargent, R. M. ;
Chambers, M. ;
Elliott, T. .
VETERINARY PARASITOLOGY, 2009, 161 (1-2) :133-137
[45]   A comparison of persistent anthelmintic efficacy of topical formulations of doramectin, ivermectin, eprinomectin and moxidectin against naturally acquired nematode infections of beef calves [J].
Williams, JC ;
Loyacano, AF ;
DeRosa, A ;
Gurie, J ;
Clymer, BC ;
Guerino, F .
VETERINARY PARASITOLOGY, 1999, 85 (04) :277-288
[46]   Controlled field efficacy of injectable moxidectin against naturally acquired psoroptic mange in sheep [J].
Ortega-Mora, LM ;
Diez-Banos, N ;
Martinez-Gonzalez, B ;
Rojo-Vazquez, FA .
SMALL RUMINANT RESEARCH, 1998, 29 (03) :271-276
[47]   Evaluation of the efficacy and persistence of moxidectin (10%) and ivermectin (3.15%) against natural infestation of gastrointestinal nematodes in cattle from the Mexican tropics [J].
Rodriguez-Vivas, R. I. ;
Castillo-Chab, C. G. ;
Rosado-Aguilar, J. A. ;
Ojeda-Chi, M. M. .
ARCHIVOS DE MEDICINA VETERINARIA, 2014, 46 (01) :69-74
[48]   Field evaluation of the efficacy and the safety of a combination of oxantel/pyrantel/praziquantel in the treatment of naturally acquired gastrointestinal nematode and/or cestode infestations in dogs in Europe [J].
Grandemange, E. ;
Claerebout, E. ;
Genchi, C. ;
Franc, M. .
VETERINARY PARASITOLOGY, 2007, 145 (1-2) :94-99
[49]   The efficacy of eprinomectin extended-release injection against naturally acquired nematode parasites of cattle, with special regard to inhibited fourth-stage Ostertagia larvae [J].
Hunter, J. S., III ;
Yoon, S. ;
Yazwinski, T. A. ;
Williams, J. C. ;
Rehbein, S. .
VETERINARY PARASITOLOGY, 2013, 192 (04) :346-352
[50]   Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia [J].
Hosking, B. C. ;
Griffiths, T. M. ;
Woodgate, R. G. ;
Besier, R. B. ;
Le Feuvre, A. S. ;
Nilon, P. ;
Trengove, C. ;
Vanhoff, K. J. ;
Kaye-Smith, B. G. ;
Seewaldf, W. .
AUSTRALIAN VETERINARY JOURNAL, 2009, 87 (11) :455-462