Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America

Seven studies were conducted under field conditions in North America to evaluate the therapeutic efficacy of doramectin in a pour-on formulation at a dosage of 500 mu g/kg (1 ml/10 kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Cooperia, and Oesophagostomum. In each study, 40 to 100 cattle were randomly allocated to a saline- or doramectin-treated group in a tiered manner based on Day -7 bodyweight. On Day 0, the cattle received either saline or doramectin topically, according to their treatment group. Weather and safety observations were made following treatment. No adverse reaction to treatment was observed at any time during these studies. Fecal egg count (FEC) determinations were carried out on each animal on Days -7, 0, 7, 14, and 21. Reductions in FEC for the doramectin-treated animals compared to saline-treated cattle were greater than or equal to 96.0% by Day -7 and greater than or equal to 99.0% on Days 14 and 21 for each study. Across all studies regardless of weather conditions, the reduction by Day 21 for the doramectin-treated animals compared to saline controls was 99.7% (p less than or equal to 0.0001) and compared to pretreatment levels in doramectin-treated cattle was 99.9% (p less than or equal to 0.0001). Doramectin pour-on should provide a useful new treatment for controlling nematode parasites of cattle. (C) 1998 Elsevier Science B.V.