Butyrolactones from the Fungus Aspergillus terreus BCC 4651

被引：83

作者：

Haritakun, Rachada ^{[1
]}

Rachtawee, Pranee ^{[1
]}

Chanthaket, Rungtiwa ^{[1
]}

Boonyuen, Nattawut ^{[1
]}

Isaka, Masahiko ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol, Klongluang 12120, Pathumthani, Thailand

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 11期

关键词：

Aspergillus terreus; butyrolactone; antimalarial activity; antitubercular activity; METABOLIC PRODUCTS; I DERIVATIVES; CDC2; KINASE; STRAIN; INHIBITOR;

D O I：

10.1248/cpb.58.1545

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new butenolides, butyrolactones VI (1) and VII (2), were isolated together with six known compounds, butyrolactones I (3), II (4), IV (5), and V (6), aspernolide B (7), and bisdethiodi(methylthio)acetylaranotin (8) from the fungus Aspergillus terreus BCC 4651. Compound 8, exhibiting a minimum inhibitory concentration (MIC) value of 1.56 mu g/ml against Mycobacterium tuberculosis H37Ra, proved to be the antimycobacterial principle from the culture of this fungus. On the other hand, butyrolactone V (6) showed antiplasmodial activity against Plasmodium falciparum K1 with an IC50 of 7.9 mu g/ml.

引用

页码：1545 / 1548

页数：4

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