Fibrinogen to Albumin Ratio as an Independent Risk Factor for Type 2 Diabetic Kidney Disease

被引:19
作者
Wang, Kai [1 ,2 ]
Xu, Wenjun [3 ]
Zha, Bingbing [1 ]
Shi, Jindong [1 ,2 ]
Wu, Guowei [3 ]
Ding, Heyuan [1 ,3 ]
机构
[1] Fudan Univ, Shanghai Peoples Hosp 5, Dept Endocrinol, 801 Heqing Rd, Shanghai 200240, Peoples R China
[2] Fudan Univ, Shanghai Peoples Hosp 5, Dept Resp & Crit Care Med, Shanghai, Peoples R China
[3] Zhejiang Kaihua Cty Hosp Chinese Med, Dept Nephrol, 10 Zhongshan Rd, Quzhou 324399, Zhejiang, Peoples R China
来源
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2021年 / 14卷
关键词
  type 2 diabetes mellitus; diabetic kidney disease; inflammation; fibrinogen to albumin ratio; NEUTROPHIL-LYMPHOCYTE RATIO; GLOMERULAR-FILTRATION-RATE; HUMAN SERUM-ALBUMIN; INFLAMMATORY BIOMARKERS; PREOPERATIVE FIBRINOGEN; NEPHROPATHY; COMPLICATIONS; ASSOCIATION;
D O I
10.2147/DMSO.S337986
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Diabetic kidney disease (DKD) is an inflammatory disease. This study aimed to investigate the association of fibrinogen to albumin ratio (FAR) with DKD. Patients and Methods: A total of 1022 type 2 diabetes mellitus (T2DM) patients with DKD and 1203 T2DM patients without DKD were enrolled in this study. Laboratory values including blood cell count, hemoglobin A1c, biochemical parameters, and fibrinogen and albumin creatinine ratio were recorded. Patients were classified according to tertile of admission FAR. Clinical parameters were compared between groups. Logistic regression, linear regression, ROC analysis and spline regression were carried out. Results: FAR in the DKD group was significantly higher than that in the non-DKD group. FAR had the highest odds ratio as an independent risk factor for the development of DKD and the highest area under ROC curve for predicting DKD compared with albumin (ALB) or fibrinogen (FIB) alone. Simple linear regression analyses revealed a significant and linear correlation of FAR with neutrophil and neutrophil-to-lymphocyte ratio. FAR was an inde-pendent risk factor for development of DKD. Spline regression showed that there was a significant linear association between DKD incidence and continuous FAR value when it exceeded 67.3mg/g. Conclusion: FAR is a stronger independent predictor of DKD than FIB and ALB. FAR is an independent risk factor for DKD development when it exceeded 67.3mg/g. FAR might be one of novel diagnostic biomarkers to predict and prevent DKD progression. However, a prospective study to validate the prognostic model is still needed.
引用
收藏
页码:4557 / 4567
页数:11
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