18F-FDG PET/CT Osteometabolic Activity in Metastatic Parathyroid Carcinoma

被引：6

作者：

Bueno do Vale, Romulo Hermeto ^{[1
]}

Queiroz, Marcelo Araujo ^{[1
]}

Novaes Coutinho, Artur Martins ^{[1
]}

Buchpiguel, Carlos Alberto ^{[1
]}

de Menezes, Marcos Roberto ^{[1
]}

机构：

[1] Sao Paulo State Canc Inst, Div Nucl Med, 4 SS Doutor Arnaldo Ave,251, Sao Paulo, Brazil

来源：

CLINICAL NUCLEAR MEDICINE | 2016年 / 41卷 / 09期

关键词：

parathyroid cancer; PET/CT; calcium; PTH; bone FDG uptake; OSTEOCLAST DIFFERENTIATION; METABOLISM; CANCER;

D O I：

10.1097/RLU.0000000000001278

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Parathyroid cancer is an uncommon type of malignancy, which is frequently associated with poor prognosis. Clinical manifestations are caused by elevated serum calcium and parathyroid hormone (PTH). Diagnostic imaging studies as neck ultrasonography, technetium Tc Tc-99m-sestamibi whole body scintigraphy, CT, and MR are already established tools for this malignancy. Nevertheless, the role of F-18-FDG PET/CT remains unknown in this scenario, with few published studies in literature. Hence, in this article, we aimed to report an illustrative case of increased skeletal FDG uptake associated with high calcium and PTH levels.

引用

页码：724 / 725

页数：2

共 8 条

[1] Miscellaneous Indications in Bone Scintigraphy: Metabolic Bone Diseases and Malignant Bone Tumors [J].

Cook, Gary J. R. ;

Gnanasegaran, Gopinath ;

Chua, Sue .

SEMINARS IN NUCLEAR MEDICINE, 2010, 40 (01) :52-61

[2] MICROCYTOPHOTOMETRIC ANALYSIS OF HUMAN OSTEOCLAST METABOLISM - LACK OF ACTIVITY IN CERTAIN OXIDATIVE PATHWAYS INDICATES INABILITY TO SUSTAIN BIOSYNTHESIS DURING RESORPTION [J].

DODDS, RA ;

GOWEN, M ;

BRADBEER, JN .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1994, 42 (05) :599-606

[3] FDG-PET/CT and parathyroid carcinoma: Review of literature and illustrative case series [J].

Evangelista, Laura ;

Sorgato, Nadia ;

Torresan, Francesca ;

Boschin, Isabella Merante ;

Pennelli, Gianmaria ;

Saladini, Giorgio ;

Piotto, Andrea ;

Rubello, Domenico ;

Pelizzo, Maria Rosa .

WORLD JOURNAL OF CLINICAL ONCOLOGY, 2011, 2 (10) :348-354

[4] Metabolic Regulation of Osteoclast Differentiation and Function [J].

Indo, Yoriko ;

Takeshita, Sunao ;

Ishii, Kiyo-Aki ;

Hoshii, Takayuki ;

Aburatani, Hiroyuki ;

Hirao, Atsushi ;

Ikeda, Kyoji .

JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (11) :2392-2399

[5] Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-Stimulated osteoclast differentiation [J].

Kim, Jin-Man ;

Jeong, Daewon ;

Kang, Hyun Ki ;

Jung, Sung Youn ;

Kang, Sam Sik ;

Min, Byung-Moo .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2007, 20 (06) :935-946

[6] Parathyroid cancer [J].

Lang, Brian ;

Lo, Chung-Yau .

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2006, 15 (03) :573-+

[7] 18F-FDG PET Findings of a Parathyroid Cancer With Cortical Skeletal Demineralization [J].

Shim, Hye-Kyung ;

Kim, Bom Sahn .

CLINICAL NUCLEAR MEDICINE, 2012, 37 (03) :293-295

[8]

WIEGMANN T, 1977, J NUCL MED, V18, P231

← 1 →