Strong inhibition of cholera toxin binding by galactose dendrimers

被引：62
作者：
Branderhorst, Hilbert M.
Liskamp, Rob M. J.
Visser, Gerben M.
Pieters, Roland J.
机构：
[1] Univ Utrecht, Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands
[2] Wageningen Univ, Organ Chem Lab, NL-6703HB Wageningen, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 47期
关键词：
D O I：
10.1039/b711070g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Galactose-containing dendrimers with long spacer arms inhibit cholera toxin binding as strongly as the natural ganglioside GM1 oligosaccharide does.
引用
收藏
页码：5043 / 5045
页数：3
相关论文
共 22 条
[1]   Ganglioside-liposome immunoassay for the ultrasensitive detection of cholera toxin [J].
Ahn-Yoon, S ;
DeCory, TR ;
Baeumner, AJ ;
Durst, RA .
ANALYTICAL CHEMISTRY, 2003, 75 (10) :2256-2261
[2]  
[Anonymous], 2006, Weekly epidemiological record
[3]   A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide [J].
Arosio, D ;
Fontanella, M ;
Baldini, L ;
Mauri, L ;
Bernardi, A ;
Casnati, A ;
Sansone, F ;
Ungaro, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (11) :3660-3661
[4]   Synthesis and cholera toxin binding properties of multivalent GM1 mimics [J].
Arosio, D ;
Vrasidas, I ;
Valentini, P ;
Liskamp, RMJ ;
Pieters, RJ ;
Bernardi, A .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (14) :2113-2124
[5]   Bacteria as potential tools in bioterrorism, with an emphasis on bacterial toxins [J].
Clarke, SC .
BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 2005, 62 (01) :40-46
[6]   AB5 toxins:: structures and inhibitor design [J].
Fan, EK ;
Merritt, EA ;
Verlinde, CLMJ ;
Hol, WGJ .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (06) :680-686
[7]   High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition [J].
Joosten, JAF ;
Tholen, NTH ;
El Maate, FA ;
Brouwer, AJ ;
van Esse, GW ;
Rijkers, DTS ;
Liskamp, RMJ ;
Pieters, RJ .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (15) :3182-3185
[8]   Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands [J].
Kitov, PI ;
Sadowska, JM ;
Mulvey, G ;
Armstrong, GD ;
Ling, H ;
Pannu, NS ;
Read, RJ ;
Bundle, DR .
NATURE, 2000, 403 (6770) :669-672
[9]  
LISKAMP RMJ, 2006, Patent No. 1733742
[10]   Strong inhibition of cholera toxin by multivalent GM1 derivatives [J].
Pukin, Aliaksei V. ;
Branderhorst, Hilbert M. ;
Sisu, Cristina ;
Weijers, Carel A. G. M. ;
Gilbert, Michel ;
Liskamp, Rob M. J. ;
Visser, Gerben M. ;
Zuilhof, Han ;
Pieters, Roland J. .
CHEMBIOCHEM, 2007, 8 (13) :1500-1503
123