Best of ASCO 2021-bladder cancer

被引：1

作者：

Mayrhofer, Karl ^{[1
]}

Niedersuess-Beke, Dora ^{[1
]}

机构：

[1] Klin Ottakring, Ctr Oncol Hematol & Palliat Care, Vienna, Austria

来源：

MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY | 2021年 / 14卷 / 04期

关键词：

Bladder preservation; Immunotherapy; Pembrolizumab; Durvalumab tremelimumab; Multimodal treatment; PEMBROLIZUMAB PEMBRO; UROTHELIAL CANCER; MIBC; GEMCITABINE; CISPLATIN; NIVOLUMAB; TRIAL; RT;

D O I：

10.1007/s12254-021-00765-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three trials presented at the meeting investigated the incorporation of immunotherapy into a multimodal bladder-sparing treatment approach. The results of these phase 2 trials are so far promising with most patients achieving complete remission (CR) and estimated bladder-intact disease-free survival (BIDFS) in these patients ranges between 73 and 88%. Additionally, the up to 5-year follow-up data from the KEYNOTE-052 study were discussed. The results confirm the efficacy of pembrolizumab as first-line monotherapy in cisplatin-ineligible patients with a programmed death ligand 1 (PD-L1) combined positive score (CPS) >= 10.

引用

页码：335 / 337

页数：3

共 6 条

[1] Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma [J].

Bajorin, D. F. ;

Witjes, J. A. ;

Gschwend, J. E. ;

Schenker, M. ;

Valderrama, B. P. ;

Tomita, Y. ;

Bamias, A. ;

Lebret, T. ;

Shariat, S. F. ;

Park, S. H. ;

Ye, D. ;

Agerbaek, M. ;

Enting, D. ;

McDermott, R. ;

Gajate, P. ;

Peer, A. ;

Milowsky, M., I ;

Nosov, A. ;

Antonio Jr, J. N. ;

Tupikowski, K. ;

Toms, L. ;

Fischer, B. S. ;

Qureshi, A. ;

Collette, S. ;

Unsal-Kacmaz, K. ;

Broughton, E. ;

Zardavas, D. ;

Koon, H. B. ;

Galsky, M. D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (22) :2102-2114

[2] Pembrolizumab (pembro) in combination with gemcitabine (Gem) and concurrent hypofractionated radiation therapy (RT) as bladder sparing treatment for muscle-invasive urothelial cancer of the bladder (MIBC): A multicenter phase 2 trial. [J].

Balar, Arjun Vasant ;

Milowsky, Matthew I. ;

O'Donnell, Peter H. ;

Alva, Ajjai Shivaram ;

Kollmeier, Marisa ;

Rose, Tracy L. ;

Pitroda, Sean ;

Kaffenberger, Samuel D. ;

Rosenberg, Jonathan E. ;

Francese, Kaitlyn ;

Hochman, Tsivia ;

Goldberg, Judith D. ;

Griglun, Sarah ;

Leis, Dayna ;

Steinberg, Gary D. ;

Wysock, James ;

Schiff, Peter B. ;

Sanfilippo, Nicholas J. ;

Taneja, Samir ;

Huang, William C. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[3] Phase 2 trial of gemcitabine, cisplatin, plus nivolumab with selective bladder sparing in patients with muscle- invasive bladder cancer (MIBC): HCRN GU 16-257. [J].

Galsky, Matt D. ;

Daneshmand, Siamak ;

Chan, Kevin G. ;

Dorff, Tanya B. ;

Cetnar, Jeremy Paul ;

Neil, Brock O. ;

D'souza, Anishka ;

Mamtani, Ronac ;

Kyriakopoulos, Christos ;

Garcia, Philip ;

Izadmehr, Sudeh ;

Yu, Menggang ;

Zhao, Qianqian ;

Mehrazin, Reza ;

Lewis, Sara C. ;

Sfakianos, John ;

Pal, Sumanta K. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[4] Phase II trial of durvalumab plus tremelimumab with concurrent radiotherapy (RT) in patients (pts) with localized muscle invasive bladder cancer (MIBC) treated with a selective bladder preservation approach: IMMUNOPRESERVE-SOGUG trial. [J].

Garcia del Muro, Xavier ;

Valderrama, Begona P. ;

Medina, Ana ;

Andres Cuellar, M. ;

Etxaniz, Olatz ;

Girones Sarrio, Regina ;

Jose Juan-Fita, Maria ;

Ferrer, Ferran ;

Miras Rodriguez, Isabel ;

Lendinez-Cano, Guillermo ;

de Haro Piedra, Roberto ;

Candal Gomez, Arturo ;

Chantada Abal, Venancio ;

Salvador Villa, Oscar Buisan ;

Luis Pontones, Jose ;

Collado, Erica ;

Dominguez-Escrig, Jose L. ;

Murria, Yashmina ;

Vigues, Francesc .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[5] First-line pembrolizumab (pembro) in cisplatin-ineligible patients with advanced urothelial cancer (UC): Response and survival results up to five years from the KEYNOTE-052 phase 2 study. [J].

O'Donnell, Peter H. ;

Balar, Arjun Vasant ;

Vuky, Jacqueline ;

Castellano, Daniel ;

Bellmunt, Joaquim ;

Powles, Thomas ;

Bajorin, Dean F. ;

Grivas, Petros ;

Hahn, Noah M. ;

Plimack, Elizabeth R. ;

Xu, Jin Zhi ;

Godwin, James Luke ;

Moreno, Blanca Homet ;

De Wit, Ronald .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[6] Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma [J].

Powles, Thomas ;

Park, Se Hoon ;

Voog, Eric ;

Caserta, Claudia ;

Valderrama, Begona P. ;

Gurney, Howard ;

Kalofonos, Haralabos ;

Radulovic, Sinisa ;

Demey, Wim ;

Ullen, Anders ;

Loriot, Yohann ;

Sridhar, Srikala S. ;

Tsuchiya, Norihiko ;

Kopyltsov, Evgeny ;

Sternberg, Cora N. ;

Bellmunt, Joaquim ;

Aragon-Ching, Jeanny B. ;

Petrylak, Daniel P. ;

Laliberte, Robert ;

Wang, Jing ;

Huang, Bo ;

Davis, Craig ;

Fowst, Camilla ;

Costa, Nuno ;

Blake-Haskins, John A. ;

di Pietro, Alessandra ;

Grivas, Petros .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (13) :1218-1230

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