Communicating with Hedgehogs

被引：669
作者：
Hooper, JE
Scott, MP
机构：
[1] Univ Colorado, Sch Med, Dept Cell & Dev Biol, Aurora, CO 80045 USA
[2] Stanford Univ, Sch Med, Howard Hughes Med Inst, Clark Ctr W252,Dept Dev Biol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Howard Hughes Med Inst, Clark Ctr W252,Dept Genet & Bioengn, Stanford, CA 94305 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 04期
关键词：
D O I：
10.1038/nrm1622
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.
引用
收藏
页码：306 / 317
页数：12
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