B-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice

被引：67
作者：
Bouxsein, ML
Pierroz, DD
Glatt, V
Goddard, DS
Cavat, F
Rizzoli, R
Ferrari, SL
机构：
[1] Beth Israel Deaconess Med Ctr, Orthoped Biomech Lab, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Hosp Geneva, Serv Bone Dis, Dept Rehabil & Geriatr, Geneva, Switzerland
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 04期
关键词：
beta-arrestin; PTH; knockout; bone architecture; bone remodeling;
D O I：
10.1359/JBMR.041204
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytoplasmic arrestins regulate PTH signaling in vitro. We show that female beta-arrestin2(-/-) mice have decreased bone mass and altered bone architecture. The effects of intermittent PTH administration on bone microarchitecture differed in beta-arrestin2(-/-) and wildtype mice. These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces.
引用
收藏
页码：635 / 643
页数：9
相关论文
共 55 条
[1]   Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice [J].
Alexander, JM ;
Bab, I ;
Fish, S ;
Müller, R ;
Uchiyama, T ;
Gronowicz, G ;
Nahounou, M ;
Zhao, Q ;
White, DW ;
Chorev, M ;
Gazit, D ;
Rosenblatt, M .
JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (09) :1665-1673
[2]  
ARMAMENTOVILLAREAL, 1997, J BONE MINER RES, V12, P384
[3]   The skeletal structure of insulin-like growth factor I-deficient mice [J].
Bikle, D ;
Majumdar, S ;
Laib, A ;
Powell-Braxton, L ;
Rosen, C ;
Beamer, W ;
Nauman, E ;
Leary, C ;
Halloran, B .
JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (12) :2320-2329
[4]   Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations [J].
Bisello, A ;
Chorev, M ;
Rosenblatt, M ;
Monticelli, L ;
Mierke, DF ;
Ferrari, SL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (41) :38524-38530
[5]   The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis [J].
Black, DM ;
Greenspan, SL ;
Ensrud, KE ;
Palermo, L ;
McGowan, JA ;
Lang, TF ;
Garnero, P ;
Bouxsein, ML ;
Bilezikian, JP ;
Rosen, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (13) :1207-1215
[6]  
Bliziotes M, 1996, J BONE MINER RES, V11, P820
[7]   Enhanced morphine analgesia in mice lacking β-arrestin 2 [J].
Bohn, LM ;
Lefkowitz, RJ ;
Gainetdinov, RR ;
Peppel, K ;
Caron, MG ;
Lin, FT .
SCIENCE, 1999, 286 (5449) :2495-2498
[8]  
Bohn LM, 2002, J NEUROSCI, V22, P10494
[9]  
Bouxsein ML, 2002, J BONE MINER RES, V17, pS140
[10]   Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo [J].
Bouxsein, ML ;
Rosen, CJ ;
Turner, CH ;
Ackert, CL ;
Shultz, KL ;
Donahue, LR ;
Churchill, G ;
Adamo, ML ;
Powell, DR ;
Turner, RT ;
Müller, R ;
Beamer, WG .
JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (04) :570-579
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