Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

被引：504
作者：
Guarnerio, Jlenia [1 ,2 ]
Bezzi, Marco [1 ,2 ]
Jeong, Jong Cheol [2 ]
Paffenholz, Stella V. [1 ,2 ]
Berry, Kelsey [1 ,2 ]
Naldini, Matteo M. [1 ,2 ]
Lo-Coco, Francesco [3 ,4 ]
Tay, Yvonne [5 ,6 ]
Beck, Andrew H. [2 ]
Pandolfi, Pier Paolo [1 ,2 ]
机构：
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Beth Israel Deaconess Canc Ctr, Canc Res Inst,Dept Med,Med Sch, Boston, MA 02215 USA
[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Beth Israel Deaconess Canc Ctr, Canc Res Inst,Dept Pathol,Med Sch, Boston, MA 02215 USA
[3] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00173 Rome, Italy
[4] Fdn Santa Lucia, I-00173 Rome, Italy
[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Canc Sci Inst Singapore, Singapore 117597, Singapore
[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore
来源：
CELL | 2016年 / 165卷 / 02期
关键词：
ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOID-LEUKEMIA; CIRCULAR RNAS; CELL-LINE; MICRORNA; TRANSCRIPTION; SEQUENCES; DIAGNOSIS; BIOMARKER; PROTEINS;
D O I：
10.1016/j.cell.2016.03.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromosomal translocations encode oncogenic fusion proteins that have been proven to be causally involved in tumorigenesis. Our understanding of whether such genomic alterations also affect non-coding RNAs is limited, and their impact on circular RNAs (circRNAs) has not been explored. Here, we show that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs (f-circRNA) that are produced from transcribed exons of distinct genes affected by the translocations. F-circRNAs contribute to cellular transformation, promote cell viability and resistance upon therapy, and have tumor-promoting properties in in vivo models. Our work expands the current knowledge regarding molecular mechanisms involved in cancer onset and progression, with potential diagnostic and therapeutic implications.
引用
收藏
页码：289 / 302
页数：14
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