Perspectives on the Risk-Stratified Treatment of Multiple Myeloma

被引：31

作者：

Davies, Faith E. ^{[1
]}

Pawlyn, Charlotte ^{[2
,3
]}

Usmani, Saad Z. ^{[4
]}

San-Miguel, Jesus F. ^{[5
]}

Einsele, Hermann ^{[6
]}

Boyle, Eileen M. ^{[1
]}

Corre, Jill ^{[7
,8
]}

Auclair, Daniel ^{[9
]}

Cho, Hearn Jay ^{[9
,10
]}

Lonial, Sagar ^{[11
]}

Sonneveld, Pieter ^{[12
]}

Stewart, A. Keith ^{[13
,14
]}

Bergsagel, P. Leif ^{[15
]}

Kaiser, Martin F. ^{[3
,16
]}

Weisel, Katja ^{[17
]}

Keats, Jonathan J. ^{[18
]}

Mikhael, Joseph R. ^{[19
]}

Morgan, Kathryn E. ^{[20
]}

Ghobrial, Irene M. ^{[21
]}

Orlowski, Robert Z. ^{[22
]}

Landgren, C. Ola ^{[23
]}

Gay, Francesca ^{[24
]}

Caers, Joseph ^{[25
]}

Chng, Wee Joo ^{[26
,27
,28
,29
]}

Chari, Ajai ^{[10
]}

Walker, Brian A. ^{[30
]}

Kumar, Shaji K. ^{[31
]}

Costa, Luciano J. ^{[32
]}

Anderson, Kenneth C. ^{[21
]}

Morgan, Gareth J. ^{[1
]}

机构：

[1] NYU Langone, Perlmutter Canc Ctr, New York, NY USA

[2] Inst Canc Res, Div Canc Therapeut, London, England

[3] Royal Marsden Hosp, Dept Haematol, London, England

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Myeloma Serv, 1275 York Ave, New York, NY 10021 USA

[5] Clin Univ Navarra, CIBERONC, IDISNA, CIMA, Pamplona, Spain

[6] Univ Hosp Wurzburg, Dept Internal Med 2, Wurzburg, Germany

[7] Inst Univ Canc, Unite Genom Myelome, Toulouse, France

[8] Inst Natl Sante & Rech Med, Paris, France

[9] Multiple Myeloma Res Fdn, Norwalk, CT USA

[10] Icahn Sch Med Mt Sinai, Multiple Myeloma Ctr Excellence, New York, NY 10029 USA

[11] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[12] Erasmus MC Canc Inst, Dept Hematol, Rotterdam, Netherlands

[13] Univ Hlth Network, Toronto, ON, Canada

[14] Princess Margaret Canc Ctr, Toronto, ON, Canada

[15] Mayo Clin, Dept Med, Phoenix, AZ USA

[16] Inst Canc Res, Div Genet & Epidemiol, London, England

[17] Univ Med Ctr Hamburg Eppendorf, Dept Oncol Hematol & Bone Marrow Transplantat, Sect Pneumol, Hamburg, Germany

[18] Translat Genom Res Inst, Integrated Canc Genom, Phoenix, AZ USA

[19] City Hope Canc Ctr, Translat Genom Res Inst, Phoenix, AZ USA

[20] Myeloma Patients Europe, Brussels, Belgium

[21] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[22] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[23] Univ Miami, Sylvester Comprehens Canc Ctr, Myeloma Program, Miami, FL USA

[24] Univ Torino, Div Hematol, Turin, Italy

[25] Ctr Hosp Univ CHU Liege, Dept Hematol, Liege, Belgium

[26] Natl Univ Canc Inst, Singapore, Singapore

[27] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

[28] Natl Univ Singapore, NUS Ctr Canc Res, Yong Loo Lin Sch Med, Singapore, Singapore

[29] Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore

[30] Indiana Univ, Melvin & Bren Simon Comprehens Canc Ctr, Div Hematol Oncol, Indianapolis, IN USA

[31] Mayo Clin, Dept Hematol, Rochester, MN USA

[32] Univ Alabama Birmingham, Dept Med, Div Hematol & Oncol, Birmingham, AL 35294 USA

来源：

BLOOD CANCER DISCOVERY | 2022年 / 3卷 / 07期

关键词：

STEM-CELL TRANSPLANTATION; INTERNATIONAL STAGING SYSTEM; MINIMAL RESIDUAL DISEASE; TERM-FOLLOW-UP; LENALIDOMIDE MAINTENANCE; PLUS BORTEZOMIB; GENE-EXPRESSION; DOUBLE-BLIND; DEXAMETHASONE; THERAPY;

D O I：

10.1158/2643-3230.BCD-21-0205

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The multiple myeloma treatment landscape has changed dramatically. This change, paralleled by an increase in scientific knowledge, has resulted in significant improvement in survival. However, heterogeneity remains in clinical outcomes, with a proportion of patients not benefiting from current approaches and continu-ing to have a poor prognosis. A significant proportion of the variability in outcome can be predicted on the basis of clinical and biochemical parameters and tumor-acquired genetic variants, allowing for risk stratification and a more personalized approach to therapy. This article discusses the principles that can enable the rational and effective development of therapeutic approaches for high-risk multiple myeloma.

引用

页码：273 / 284

页数：12

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