Aptamer-Modified Hydrogels

被引：2

作者：

Walter, Johanna-Gabriela ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Tech Chem, Hannover, Germany

来源：

TUNABLE HYDROGELS: SMART MATERIALS FOR BIOMEDICAL APPLICATIONS | 2021年 / 178卷

关键词：

Aptamers; Biomedicine; Biosensing; Hydrogels; Target-responsive hydrogels; CROSS-LINKED HYDROGEL; NUCLEIC-ACID APTAMERS; FUNCTIONALIZED HYDROGEL; QUANTITATIVE DETECTION; ADAPTIVE RECOGNITION; CELL-ADHESION; DNA HYDROGEL; IN-VITRO; RELEASE; APTASENSOR;

D O I：

10.1007/10_2021_166

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hydrogels have attracted much attention especially due to their biocompatibility and their potential for stimulus responsiveness. By combining hydrogels with aptamers, biological recognition and responsiveness can be added to hydrogels, thereby opening path to advanced applications in biosensing and biomedicine. Within this chapter aptamers will be introduced and their contributions to biological responsiveness of hydrogels will be described. Especially the aptamer-based mechanisms that result in biological responsiveness will be explained and examples for the application of these mechanisms will be given ranging from rather simple sensing approaches to advanced materials for tissue engineering and drug delivery. Since aptamers are not only highly specific bioreceptors, but represent switchable structures that can be easily manipulated using well-known DNA techniques, the combination of aptamers and hydrogels facilitates the rational design of well-programmable and target-responsive smart hydrogels. [GRAPHICS] .

引用

页码：147 / 168

页数：22

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