Asymmetric desymmetrization of meso-1,2-diols by phosphinite derivatives of cinchona alkaloids

被引：75

作者：

Mizuta, S ^{[1
]}

Sadamori, M ^{[1
]}

Fujimoto, T ^{[1
]}

Yamamoto, I ^{[1
]}

机构：

[1] Shinshu Univ, Dept Funct Polymer Sci, Ueda, Nagano 3868567, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 29期

关键词：

alkaloids; asymmetric catalysis; desymmetrization; diols; phosphorus;

D O I：

10.1002/anie.200250719

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An effective catalyst for the asymmetric monobenzoylation of meso-1, 2-diols was designed - the phosphinite derivative of cinchonine (see formula). In the presence of 30 mol % of this catalyst the monobenzoylated products were obtained with high yields and enantioselectivities.

引用

页码：3383 / 3385

页数：3

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