Anti-inflammatory genes associated with multiple sclerosis: A gene expression study

被引：21

作者：

Perga, S. ^{[1
,2
]}

Montarolo, F. ^{[1
,2
]}

Martire, S. ^{[1
,2
]}

Berchialla, P. ^{[3
]}

Malucchi, S. ^{[2
]}

Bertolotto, A. ^{[1
,2
]}

机构：

[1] Neurosci Inst Cavalieri Ottolenghi, Orbassano, TO, Italy

[2] Univ Hosp San Luigi Gonzaga, Neurobiol Unit, Neurol CReSM Ctr Riferimento Reg Sclerosi Multipl, Orbassano, TO, Italy

[3] Univ Turin, Dept Clin & Biol Sci, Turin, TO, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 279卷

关键词：

Multiple sclerosis; Inflammation; Gene expression; GWAS; INFLAMMATION; DISEASE; PROTEINS; ROLES; LOCUS; RISK;

D O I：

10.1016/j.jneuroim.2015.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sderosis (MS) is an autoimmune inflammatory disease of the central nervous system caused by a complex interaction between multiple genes and environmental factors. HLA region is the strongest susceptibility locus, but recent huge genome-wide association studies identified new susceptibility genes. Among these, BACH2, PTGER4, RGS1 and ZFP36L1 were highlighted. Here, a gene expression analysis revealed that three of them, namely BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. Interestingly, all these genes are involved in the immune system regulation with predominant anti-inflammatory role and their reduction could predispose to MS development. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：75 / 78

页数：4

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