Micronuclei in lymphocytes of children from the vicinity of Chernobyl before and after I-131 therapy for thyroid cancer

被引:38
作者
Wuttke, K
Streffer, C
Muller, WU
Reiners, C
Biko, J
Demidchik, E
机构
[1] UNIV ESSEN GESAMTHSCH KLINIKUM, INST MED STRAHLENBIOL, D-45122 ESSEN, GERMANY
[2] UNIV ESSEN GESAMTHSCH KLINIKUM, NUKL MED KLIN & POLIKLIN, D-45122 ESSEN, GERMANY
[3] CTR THYROID TUMORS, MINSK, BELARUS
关键词
D O I
10.1080/095530096146101
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The present study addresses the monitoring of children from the Belorussian and Ukrainian Republics exposed to the fall-out of the Chernobyl accident. Micronucleus analysis has been performed on 56 children from different areas. The micronucleus frequencies in individuals as well as in regional groups were comparable with controls, except for three donors. Such results had to be expected, taking into account that at least 7 years have passed since the accident. Most of the children whose micronucleus frequencies were determined are suffering from thyroid cancer and were treated by radioiodine (I-131) therapy. We studied the effect of in vitro exposure with I-131 on micronucleus induction and that proliferative ability of lymphocytes. The present investigation indicates that micronuclei can be usefully employed to detect individual exposures to the incorporated radionuclide within several days after the intake of the radionuclide in a dose range of around 65-390 mGy (effective dose).
引用
收藏
页码:259 / 268
页数:10
相关论文
共 50 条
  • [31] I-123 and I-131 scintigraphy discordance in pediatric thyroid cancer; effect of previous I-131 therapy.
    Robertson, Matthew
    Voss, Stephan
    Grant, Frederick
    Smith, Jessica
    JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (03)
  • [32] Radiation Dose Measurement in I-131 Therapy Room of Thyroid Cancer
    Hyun, I.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 : S350 - S350
  • [33] KINETICS OF LARGE THERAPY DOSES OF I-131 IN PATIENTS WITH THYROID CANCER
    SINGH, B
    SHARMA, SM
    PATEL, MC
    RAGHAVEN.KV
    BERMAN, M
    JOURNAL OF NUCLEAR MEDICINE, 1974, 15 (08) : 674 - 678
  • [34] RADIOACTIVE I-131 OVER TAIWAN AFTER THE CHERNOBYL ACCIDENT
    CHUNG, C
    LO, JG
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-LETTERS, 1986, 105 (06): : 325 - 333
  • [35] The influence of I-131 therapy on FDG uptake in differentiated thyroid cancer
    Hung, Guang-Uei
    Lee, Kwo-Whei
    Liao, Pei-Yung
    Yang, Li-Heng
    Yang, Kwang-Tao
    ANNALS OF NUCLEAR MEDICINE, 2008, 22 (06) : 481 - 485
  • [36] DNA repair focus formation in blood cells after thyroid cancer therapy with I-131
    Lassmann, M.
    Haenscheid, H.
    Gassen, D.
    Hategan, M.
    Nerlich, K.
    Verburg, F. A.
    Meineke, V.
    Reiners, C.
    Scherthan, H.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 : S258 - S258
  • [37] DNA repair focus formation in blood cells after thyroid cancer therapy with I-131
    Lassmann, M.
    Haenscheid, H.
    Gassen, D.
    Hategan, M.
    Nerlich, K.
    Verburg, F. A.
    Meineke, V.
    Reiners, C.
    Scherthan, H.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 (SUPPL 2) : 258 - 258
  • [38] HYPOPARATHYROIDISM AFTER I-131 THERAPY
    FULOP, M
    ANNALS OF INTERNAL MEDICINE, 1971, 75 (05) : 808 - +
  • [39] I-131 CONTAMINATION FROM THYROID-CANCER PATIENTS
    IBIS, E
    WILSON, CR
    COLLIER, BD
    AKANSEL, G
    ISITMAN, AT
    YOSS, RG
    JOURNAL OF NUCLEAR MEDICINE, 1992, 33 (12) : 2110 - 2115
  • [40] The influence of I-131 therapy on FDG uptake in differentiated thyroid cancer
    Guang-Uei Hung
    Kwo-Whei Lee
    Pei-Yung Liao
    Li-Heng Yang
    Kwang-Tao Yang
    Annals of Nuclear Medicine, 2008, 22 : 481 - 485