Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

被引：26

作者：

Fritsche, Ellen ^{[1
,2
]}

Barenys, Marta ^{[3
]}

Klose, Joerdis ^{[1
]}

Masjosthusmann, Stefan ^{[1
]}

Nimtz, Laura ^{[1
]}

Schmuck, Martin ^{[1
]}

Wuttke, Saskia ^{[1
]}

Tigges, Julia ^{[1
]}

机构：

[1] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ, D-40225 Dusseldorf, Germany

[3] Univ Barcelona, Barcelona, Spain

来源：

TOXICOLOGICAL SCIENCES | 2018年 / 165卷 / 01期

关键词：

stem cells; ESC; cellular and molecular biology; CENTRAL-NERVOUS-SYSTEM; NEURAL PROGENITOR CELLS; IN-VITRO; REGULATORY PURPOSES; MCT8; DEFICIENCY; RADIAL GLIA; BRAIN; DNT; NEUROGENESIS; CHEMICALS;

D O I：

10.1093/toxsci/kfy175

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery.

引用

页码：14 / 20

页数：7

共 85 条

[81]

World Health Organization/United Nations Environment Programme, 2012, TOXICOL LETT, DOI DOI 10.1016/J.TOXLET.2012.03.020

[82] Apaf1 is required for mitochondrial pathways of apoptosis and brain development [J].