Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

被引：26

作者：

Fritsche, Ellen ^{[1
,2
]}

Barenys, Marta ^{[3
]}

Klose, Joerdis ^{[1
]}

Masjosthusmann, Stefan ^{[1
]}

Nimtz, Laura ^{[1
]}

Schmuck, Martin ^{[1
]}

Wuttke, Saskia ^{[1
]}

Tigges, Julia ^{[1
]}

机构：

[1] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ, D-40225 Dusseldorf, Germany

[3] Univ Barcelona, Barcelona, Spain

来源：

TOXICOLOGICAL SCIENCES | 2018年 / 165卷 / 01期

关键词：

stem cells; ESC; cellular and molecular biology; CENTRAL-NERVOUS-SYSTEM; NEURAL PROGENITOR CELLS; IN-VITRO; REGULATORY PURPOSES; MCT8; DEFICIENCY; RADIAL GLIA; BRAIN; DNT; NEUROGENESIS; CHEMICALS;

D O I：

10.1093/toxsci/kfy175

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery.

引用

页码：14 / 20

页数：7

共 85 条

[1] Gender and age related changes in number of dopaminergic neurons in adult human olfactory bulb [J].

Afizadeh, Rafieh ;

Hassanzadeh, Gholamreza ;

Soleimani, Mansoureh ;

Joghataei, Mohammad Taghi ;

Siavashi, Vahid ;

Khorgami, Zhinoos ;

Hadjighassem, Mahmoudreza .

JOURNAL OF CHEMICAL NEUROANATOMY, 2015, 69 :1-6

[2]

[Anonymous], 2002, HORMONES BRAIN BEHAV, DOI DOI 10.1016/B978-012532104-4/50071-8

[3] How to make a midbrain dopaminergic neuron [J].

Arenas, Ernest ;

Denham, Mark ;

Villaescusa, J. Carlos .

DEVELOPMENT, 2015, 142 (11) :1918-1936

[4] Equal Numbers of Neuronal and Nonneuronal Cells Make the Human Brain an Isometrically Scaled-Up Primate Brain [J].

Azevedo, Frederico A. C. ;

Carvalho, Ludmila R. B. ;

Grinberg, Lea T. ;

Farfel, Jose Marcelo ;

Ferretti, Renata E. L. ;

Leite, Renata E. P. ;

Jacob Filho, Wilson ;

Lent, Roberto ;

Herculano-Houzel, Suzana .

JOURNAL OF COMPARATIVE NEUROLOGY, 2009, 513 (05) :532-541

[5] Building a developmental toxicity ontology [J].

Baker, Nancy ;

Boobis, Alan ;

Burgoon, Lyle ;

Carney, Edward ;

Currie, Richard ;

Fritsche, Ellen ;

Knudsen, Thomas ;

Laffont, Madeleine ;

Piersma, Aldert H. ;

Poole, Alan ;

Schneider, Steffen ;

Daston, George .

BIRTH DEFECTS RESEARCH, 2018, 110 (06) :502-518

[6] Recommendation on Test Readiness Criteria for New Approach Methods in Toxicology: Exemplified for Developmental Neurotoxicity [J].

Bal-Price, Anna ;

Hogberg, Helena T. ;

Crofton, Kevin M. ;

Daneshian, Mardas ;

FitzGerald, Rex E. ;

Fritsche, Ellen ;

Heinonen, Tuula ;

Bennekou, Susanne Hougaard ;

Klima, Stefanie ;

Piersma, Aldert H. ;

Sachana, Magdalini ;

Shafer, Timothy J. ;

Terron, Andrea ;

Monnet-Tschudi, Florianne ;

Viviani, Barbara ;

Waldmann, Tanja ;

Westerink, Remco H. S. ;

Wilks, Martin F. ;

Witters, Hilda ;

Zurich, Marie-Gabrielle ;

Leist, Marcel .

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2018, 35 (03) :306-352

[7] International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes [J].

Bal-Price, Anna ;

Crofton, Kevin M. ;

Leist, Marcel ;

Allen, Sandra ;

Arand, Michael ;

Buetler, Timo ;

Delrue, Nathalie ;

FitzGerald, Rex E. ;

Hartung, Thomas ;

Heinonen, Tuula ;

Hogberg, Helena ;

Bennekou, Susanne Hougaard ;

Lichtensteiger, Walter ;

Oggier, Daniela ;

Paparella, Martin ;

Axelstad, Marta ;

Piersma, Aldert ;

Rached, Eva ;

Schilter, BenoIt ;

Schmuck, Gabriele ;

Stoppini, Luc ;

Tongiorgi, Enrico ;

Tiramani, Manuela ;

Monnet-Tschudi, Florianne ;

Wilks, Martin F. ;

Ylikomi, Timo ;

Fritsche, Ellen .

ARCHIVES OF TOXICOLOGY, 2015, 89 (02) :269-287

[8] Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation [J].

Bal-Price, Anna K. ;

Coecke, Sandra ;

Costa, Lucio ;

Crofton, Kevin M. ;

Fritsche, Ellen ;

Goldberg, Alan ;

Grandjean, Philippe ;

Lein, Pamela J. ;

Li, Abby ;

Lucchini, Roberto ;

Mundy, William R. ;

Padilla, Stephanie ;

Persico, Antonio M. ;

Seiler, Andrea E. M. ;

Kreysa, Joachim .

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2012, 29 (02) :202-215

[9] A developmental and genetic classification for malformations of cortical development [J].

Barkovich, AJ ;

Kuzniecky, RI ;

Jackson, GD ;

Guerrini, R ;

Dobyns, WB .

NEUROLOGY, 2005, 65 (12) :1873-1887

[10] Biology of oligodendrocyte and myelin in the mammalian central nervous system [J].

Baumann, N ;

Pham-Dinh, D .

PHYSIOLOGICAL REVIEWS, 2001, 81 (02) :871-927

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