Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

被引：25
作者：
Fritsche, Ellen [1 ,2 ]
Barenys, Marta [3 ]
Klose, Joerdis [1 ]
Masjosthusmann, Stefan [1 ]
Nimtz, Laura [1 ]
Schmuck, Martin [1 ]
Wuttke, Saskia [1 ]
Tigges, Julia [1 ]
机构：
[1] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany
[2] Heinrich Heine Univ, D-40225 Dusseldorf, Germany
[3] Univ Barcelona, Barcelona, Spain
来源：
TOXICOLOGICAL SCIENCES | 2018年 / 165卷 / 01期
关键词：
stem cells; ESC; cellular and molecular biology; CENTRAL-NERVOUS-SYSTEM; NEURAL PROGENITOR CELLS; IN-VITRO; REGULATORY PURPOSES; MCT8; DEFICIENCY; RADIAL GLIA; BRAIN; DNT; NEUROGENESIS; CHEMICALS;
D O I：
10.1093/toxsci/kfy175
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery.
引用
收藏
页码：14 / 20
页数：7
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