Response Properties of Nucleus Reticularis Lateralis Neurons After Electroacupuncture Stimulation in Rats

被引：7

作者：

Moritaka, Kentaro ^{[1
]}

Zeredo, Jorge L. ^{[1
,2
]}

Kimoto, Mari ^{[1
,3
]}

Nasution, Fajar H. ^{[1
,4
]}

Hirano, Takafumi ^{[1
]}

Toda, Kazuo ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528588, Japan

[2] Univ Brasilia, Brasilia, DF, Brazil

[3] Japan Womens Univ, Physiol Labs, Tokyo 112, Japan

[4] Trisakti Univ, Fac Dent, Jakarta, Indonesia

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2010年 / 38卷 / 05期

关键词：

Electroacupuncture; Nucleus Reticularis Lateralis; Nucleus Raphe Magnus; Spinal Cord; Pain; Rat; DORSAL-HORN NEURONS; ROSTRAL VENTROMEDIAL MEDULLA; BRAIN-STEM NEURONS; RAPHE MAGNUS; ELECTRICAL-STIMULATION; ACUPUNCTURE ANALGESIA; PERIAQUEDUCTAL GRAY; DESCENDING CONTROL; OPIATE RECEPTORS; CELL-BODIES;

D O I：

10.1142/S0192415X10008317

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

A descending inhibitory mechanism from the periaqueductal gray (PAG) to the spinal cord through the nucleus raphe magnus (NRM) is strongly involved in endogenous analgesic system produced by acupuncture stimulation. In addition to the PAG to NRM system which descends in the medial pathway of the brain stem, the nucleus reticularis lateralis (NRL) situated in the lateral part of the brain stem is reported to play an important role in modulating centrifugal antinociceptive action. In the present study, to clarify the role of NRL in acupuncture analgesia, we investigated the response properties of NRL neurons to acupuncture stimulation. The majority of NRM-projecting NRL neurons were inhibited by electroacupuncture stimulation. This effect was antagonized by ionophoretic application of naloxone, indicating that endogenous opioids act directly onto these NRL neurons. By contrast, about half of spinal projecting NRL neurons were excited by electroacupuncture stimulation, suggesting that part of the NRL neurons may modulate pain transmission directly at the spinal level.

引用

页码：869 / 880

页数：12

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