Hepatocyte growth factor promotes migration of human myeloma cells

被引：39

作者：

Holt, Randi Utne ^{[1
,2
]}

Fagerli, Unn-Merete ^{[1
,3
]}

Baykov, Vadim ^{[1
]}

Ro, Torstein Baade ^{[1
]}

Hov, Hakon ^{[1
]}

Waage, Anders ^{[1
,4
]}

Sundan, Anders ^{[1
]}

Borset, Magne ^{[1
,5
]}

机构：

[1] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Trondheim, Norway

[2] Sor Trondelag Univ Coll, Fac Technol, Trondheim, Norway

[3] St Olavs Hosp, Dept Oncol, Trondheim, Norway

[4] St Olavs Hosp, Dept Hematol, Trondheim, Norway

[5] St Olavs Hosp, Dept Immunol & Transfus Med, Trondheim, Norway

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 04期

关键词：

myeloma; cell migration; hepatocyte growth factor; stromal cell-derived growth factor-1;

D O I：

10.3324/haematol.11867

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events. We studied migration in a Transwell two-chamber assay and tested the motogenic effect of various cytokines. In addition to insulin-like growth factor-1 and stromal cell-derived growth factor-1 alpha, previously known as chemoattractants for myeloma cells, we identified hepatocyte growth factor as a potent attractant for myeloma cells. Hepatocyte growth factor-mediated migration was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins.

引用

页码：619 / 622

页数：4

共 20 条

[1] Chemokines in multiple myeloma
Aggarwal, Rohit
Ghobrial, Irene A.
Roodman, G. David
[J]. EXPERIMENTAL HEMATOLOGY, 2006, 34 (10) : 1289 - 1295
[2] Met, metastasis, motility and more
Birchmeier, C
Birchmeier, W
Gherardi, E
Vande Woude, GF
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (12) : 915 - 925
[3] Concomitant expression of hepatocyte growth factor scatter factor and the receptor c-MET in human myeloma cell lines
Borset, M
Lien, E
Espevik, T
Helseth, E
Waage, A
Sundan, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (40) : 24655 - 24661
[4] Hepatocyte growth factor and its receptor c-met in multiple myeloma
Borset, M
HjorthHansen, H
Seidel, C
Sundan, A
Waage, A
[J]. BLOOD, 1996, 88 (10) : 3998 - 4004
[5] Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor
Broek, IV
Asosingh, K
Allegaert, V
Leleu, X
Facon, T
Vanderkerken, K
Van Camp, B
Van Riet, I
[J]. LEUKEMIA, 2004, 18 (05) : 976 - 982
[6] Chirgadze DY, 1999, NAT STRUCT BIOL, V6, P72
[7] Dalton W S, 2001, Hematology Am Soc Hematol Educ Program, P157
[8] Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
Derksen, PWB
Keehnen, RMJ
Evers, LM
van Oers, MHJ
Spaargaren, M
Pals, ST
[J]. BLOOD, 2002, 99 (04) : 1405 - 1410
[9] Reactive oxygen species mediate met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells
Fischer, OM
Giordano, S
Comoglio, PM
Ullrich, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (28) : 28970 - 28978
[10] THE PROTEIN-KINASE ENCODED BY THE AKT PROTOONCOGENE IS A TARGET OF THE PDGF-ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE
FRANKE, TF
YANG, SI
CHAN, TO
DATTA, K
KAZLAUSKAS, A
MORRISON, DK
KAPLAN, DR
TSICHLIS, PN
[J]. CELL, 1995, 81 (05) : 727 - 736

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