Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADα, and MO25α, in Peutz-Jeghers syndrome

被引：23
作者：
Alhopuro, P
Katajisto, P
Lehtonen, R
Ylisaukko-oja, SK
Näätsaari, L
Karhu, A
Westerman, AM
Wilson, JHP
de Rooij, FWM
Vogel, T
Moeslein, G
Tomlinson, IP
Aaltonen, LA
Mäkelä, TP
Launonen, V
机构：
[1] Univ Helsinki, Dept Med Genet, Biomedicum Helsinki, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Biomedicum Helsinki, Helsinki, Finland
[3] Inst Biomed, Mol Canc Biol Program, Helsinki, Finland
[4] Erasmus MC, Dept Internal Med, Lab Vasc & Metab Dis, Rotterdam, Netherlands
[5] Univ Dusseldorf, Univ Klinikum, D-4000 Dusseldorf, Germany
[6] Imperial Canc Res Fund, Mol & Populat Genet Lab, London WC2A 3PX, England
来源：
BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 06期
基金：
芬兰科学院;
关键词：
peutz-jeghers syndrome; BRG1; STRAD alpha; MO25; alpha; LKB1;
D O I：
10.1038/sj.bjc.6602454
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.
引用
收藏
页码：1126 / 1129
页数：4
相关论文
共 26 条
[1]   Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD [J].
Baas, AF ;
Boudeau, J ;
Sapkota, GP ;
Smit, L ;
Medema, R ;
Morrice, NA ;
Alessi, DR ;
Clevers, HC .
EMBO JOURNAL, 2003, 22 (12) :3062-3072
[2]   MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm [J].
Boudeau, J ;
Baas, AF ;
Deak, M ;
Morrice, NA ;
Kieloch, A ;
Schutkowski, M ;
Prescott, AR ;
Clevers, HC ;
Alessi, DR .
EMBO JOURNAL, 2003, 22 (19) :5102-5114
[3]   Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network [J].
Brajenovic, M ;
Joberty, G ;
Küster, B ;
Bouwmeester, T ;
Drewes, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12804-12811
[4]   Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2 [J].
Buchet-Poyau, K ;
Mehenni, H ;
Radhakrishna, U ;
Antonarakis, SE .
CYTOGENETIC AND GENOME RESEARCH, 2002, 97 (3-4) :171-178
[5]   A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes [J].
Bultman, S ;
Gebuhr, T ;
Yee, D ;
La Mantia, C ;
Nicholson, J ;
Gilliam, A ;
Randazzo, F ;
Metzger, D ;
Chambon, P ;
Crabtree, G ;
Magnuson, T .
MOLECULAR CELL, 2000, 6 (06) :1287-1295
[6]   Very high risk of cancer in familial Peutz-Jeghers syndrome [J].
Giardiello, FM ;
Brensinger, JD ;
Tersmette, AC ;
Goodman, SN ;
Petersen, GM ;
Booker, SV ;
Cruz-Correa, M ;
Offerhaus, JA .
GASTROENTEROLOGY, 2000, 119 (06) :1447-1453
[7]   INCREASED RISK OF CANCER IN THE PEUTZ-JEGHERS SYNDROME [J].
GIARDIELLO, FM ;
WELSH, SB ;
HAMILTON, SR ;
OFFERHAUS, GJA ;
GITTELSOHN, AM ;
BOOKER, SV ;
KRUSH, AJ ;
YARDLEY, JH ;
LUK, GD .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (24) :1511-1514
[8]  
Hawley Simon A, 2003, J Biol, V2, P28, DOI 10.1186/1475-4924-2-28
[9]   Mapping of a translocation breakpoint in a Peutz-Jeghers hamartoma to the putative PJS']JS locus at 19q13.4 and mutation analysis of candidate genes in polyp and STKII-negative PJS']JS cases [J].
Hearle, N ;
Lucassen, A ;
Wang, R ;
Lim, W ;
Ross, F ;
Wheeler, R ;
Moore, I ;
Shipley, J ;
Houlston, R .
GENES CHROMOSOMES & CANCER, 2004, 41 (02) :163-169
[10]   A serine/threonine kinase gene defective in Peutz-Jegheus syndrome [J].
Hemminki, A ;
Markie, D ;
Tomlinson, I ;
Avizienyte, E ;
Roth, S ;
Loukola, A ;
Bignell, G ;
Warren, W ;
Aminoff, M ;
Höglund, P ;
Järvinen, H ;
Kristo, P ;
Pelin, K ;
Ridanpää, M ;
Salovaara, R ;
Toro, T ;
Bodmer, W ;
Olschwang, S ;
Olsen, AS ;
Stratton, MR ;
de la Chapelle, A ;
Aaltonen, LA .
NATURE, 1998, 391 (6663) :184-187
123