Antitumor activity of polysaccharides isolated from Patrinia heterophylla

被引：14

作者：

Lu, Wen-Zong ^{[1
,2
]}

Geng, Guo-Xia ^{[3
]}

Li, Qing-Wang ^{[1
,4
]}

Li, Jian ^{[4
]}

Liu, Fu-Zhu ^{[1
]}

Han, Zeng-Sheng ^{[4
]}

机构：

[1] NW A&F Univ, Coll Anim Sci, Yangling 712100, Shaanxi Prov, Peoples R China

[2] Xian Technol Univ, Coll Elect & Informat Engn, Xian, Shaanxi Prov, Peoples R China

[3] NW A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi Prov, Peoples R China

[4] Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao, Hebei Province, Peoples R China

来源：

PHARMACEUTICAL BIOLOGY | 2010年 / 48卷 / 09期

关键词：

Antitumor; apoptosis; Patrinia heterophylla Bunge; polysaccharides; U14; CELL-CYCLE ARREST; COLON-CANCER; APOPTOSIS; P53; GROWTH; IMMUNOMODULATION; IRRADIATION; INDUCTION; ALPHA; STAGE;

D O I：

10.3109/13880200903437852

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The research investigated the effect of Patrinia heterophylla Bunge (Valerianaceae) polysaccharides (PHB-P1) on U14-bearing mice. The tumor weight of mice treated with PHB-P1 (30, 60 mg/kg body weight) was significantly lower than that of the control group, a decrease of serum lactate dehydrogenase (LDH) activity was observed, and the serum alkaline phosphatase (AKP) level was increased slightly. The number of apoptotic tumor cells was significantly increased in the mice by treatment of PHB-P1 (30, 60 mg/kgbw). Cell cycle analysis showed the accumulation of tumor cells in the G2/M phase and a relative decrease of the S phase. By the immunohistochemical analysis, PHB-P1 (30, 60 mg/kgbw) might up-regulate the expression of p53 and Bax, and significantly inhibited the expression of Bcl-2 in tumor tissues. In conclusion, PHB-P1 could inhibit tumor growth and induce tumor cell apoptosis.

引用

页码：1012 / 1017

页数：6

共 41 条

[1] Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell [J].

Cao, QZ ;

Lin, ZB .

LIFE SCIENCES, 2006, 78 (13) :1457-1463

[2] Targeting the cell cycle for cancer therapy [J].

Carnero, A .

BRITISH JOURNAL OF CANCER, 2002, 87 (02) :129-133

[3] Antiproliferative effects of dehydrocostuslactone through cell cycle arrest and apoptosis in human ovarian cancer SK-OV-3 cells [J].

Choi, Eun Jeong ;

Ahn, Woong Shick .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2009, 23 (02) :211-216

[4]

Concin N, 2003, INT J ONCOL, V22, P51

[5] Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis [J].

Fas, Stefanie C. ;

Baumann, Sven ;

Zhu, Jia Yun ;

Giaisi, Marco ;

Treiber, Monika K. ;

Mahlknecht, Ulrich ;

Krammer, Peter H. ;

Li-Weber, Min .

BLOOD, 2006, 108 (12) :3700-3706

[6]

FU Y, 2006, CHIN HERB MED, V37, P52

[7] Manipulation of the tumor suppressor p53 for potentiating cancer therapy [J].

Haupt, S ;

Haupt, Y .

SEMINARS IN CANCER BIOLOGY, 2004, 14 (04) :244-252

[8] The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer [J].

Iwakawa, Mayumi ;

Ohno, Tatsuya ;

Imadome, Kaori ;

Nakawatari, Miyako ;

Ishikawal, Ken-ichi ;

Sakai, Minako ;

Katoh, Shingo ;

Ishikawa, Hitoshi ;

Tsujii, Hirohiko ;

Imai, Takashi .

CANCER BIOLOGY & THERAPY, 2007, 6 (06) :905-911

[9] Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme [J].

Jasril ;

Mooi, LY ;

Lajis, NH ;

Ali, AM ;

Sukari, MA ;

Rahman, AA ;

Othman, AG ;

Kikuzaki, H ;

Nakatani, N .

PHARMACEUTICAL BIOLOGY, 2003, 41 (07) :506-511

[10]

JIAO LQ, 2005, CHIN ARCH TRAD CHIN, V23, P23

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