Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer

被引：87

作者：

Hench, Ivana Bratic ^{[1
]}

Hench, Jurgen ^{[1
]}

Tolnay, Markus ^{[1
]}

机构：

[1] Univ Basel Hosp, Inst Med Genet & Pathol, Basel, Switzerland

来源：

FRONTIERS IN MEDICINE | 2018年 / 5卷

关键词：

liquid biopsy; cell-free DNA; ctDNA; circulating tumor cell; cancer; screening; blood; CELL-FREE DNA; CIRCULATING TUMOR-CELLS; K-RAS MUTATIONS; PLASMA DNA; ACQUIRED-RESISTANCE; PROGNOSTIC VALUE; DISEASE PROGRESSION; SERUM DNA; NONINVASIVE DETECTION; QUANTITATIVE-ANALYSIS;

D O I：

10.3389/fmed.2018.00009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and tumor-derived exosomes, all collectively referred to as "liquid biopsies," are not only a modality to monitor treatment efficacy, disease progression, and emerging therapy resistance mechanisms, but they also assess tumor heterogeneity and evolution in real time. We review the literature concerning the examination of ctDNA and CTC in a diagnostic setting, evaluating their prognostic, predictive, and monitoring capabilities. We discuss the advantages and limitations of various leading ctDNA/CTC analysis technologies. Finally, guided by the results of clinical trials, we discuss the readiness of cell-free DNA and CTC as routine biomarkers in the context of various common types of neoplastic disease. At this moment, one cannot conclude whether or not liquid biopsy will become a mainstay in oncology practice.

引用

页数：24

共 200 条

[31] Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J].

Cristofanilli, Massimo .

SEMINARS IN ONCOLOGY, 2006, 33 (03) :S9-S14

[32] Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer [J].

Dawson, Sarah-Jane ;

Tsui, Dana W. Y. ;

Murtaza, Muhammed ;

Biggs, Heather ;

Rueda, Oscar M. ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Gale, Davina ;

Forshew, Tim ;

Mahler-Araujo, Betania ;

Rajan, Sabrina ;

Humphray, Sean ;

Becq, Jennifer ;

Halsall, David ;

Wallis, Matthew ;

Bentley, David ;

Caldas, Carlos ;

Rosenfeld, Nitzan .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (13) :1199-1209

[33] Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer [J].

de Bono, Johann S. ;

Scher, Howard I. ;

Montgomery, R. Bruce ;

Parker, Christopher ;

Miller, M. Craig ;

Tissing, Henk ;

Doyle, Gerald V. ;

Terstappen, Leon W. W. M. ;

Pienta, Kenneth J. ;

Raghavan, Derek .

CLINICAL CANCER RESEARCH, 2008, 14 (19) :6302-6309

[34] Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle [J].

De Mattos-Arruda, L. ;

Weigelt, B. ;

Cortes, J. ;

Won, H. H. ;

Ng, C. K. Y. ;

Nuciforo, P. ;

Bidard, F. -C. ;

Aura, C. ;

Saura, C. ;

Peg, V. ;

Piscuoglio, S. ;

Oliveira, M. ;

Smolders, Y. ;

Patel, P. ;

Norton, L. ;

Tabernero, J. ;

Berger, M. F. ;

Seoane, J. ;

Reis-Filho, J. S. .

ANNALS OF ONCOLOGY, 2014, 25 (09) :1729-1735

[35] Capture of Viable Circulating Tumor Cells in the Liver of Colorectal Cancer Patients [J].

Deneve, Eric ;

Riethdorf, Sabine ;

Ramos, Jeanne ;

Nocca, David ;

Coffy, Amandine ;

Daures, Jean-Pierre ;

Maudelonde, Thierry ;

Fabre, Jean-Michel ;

Pantel, Klaus ;

Alix-Panabieres, Catherine .

CLINICAL CHEMISTRY, 2013, 59 (09) :1384-1392

[36] Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery [J].

Denis, Jerome Alexandre ;

Patroni, Alexia ;

Guillerm, Erell ;

Pepin, Dominique ;

Benali-Furet, Naoual ;

Wechsler, Janine ;

Manceau, Gilles ;

Bernard, Maguy ;

Coulet, Florence ;

Larsen, Annette K. ;

Karoui, Mehdi ;

Lacorte, Jean-Marc .

MOLECULAR ONCOLOGY, 2016, 10 (08) :1221-1231

[37] The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers [J].

Diaz, Luis A., Jr. ;

Williams, Richard T. ;

Wu, Jian ;

Kinde, Isaac ;

Hecht, J. Randolph ;

Berlin, Jordan ;

Allen, Benjamin ;

Bozic, Ivana ;

Reiter, Johannes G. ;

Nowak, Martin A. ;

Kinzler, Kenneth W. ;

Oliner, Kelly S. ;

Vogelstein, Bert .

NATURE, 2012, 486 (7404) :537-540

[38] Detection and quantification of mutations in the plasma of patients with colorectal tumors [J].

Diehl, F ;

Li, M ;

Dressman, D ;

He, YP ;

Shen, D ;

Szabo, S ;

Diaz, LA ;

Goodman, SN ;

David, KA ;

Juhl, H ;

Kinzler, KW ;

Vogelstein, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (45) :16368-16373

[39] Circulating mutant DNA to assess tumor dynamics [J].

Diehl, Frank ;

Schmidt, Kerstin ;

Choti, Michael A. ;

Romans, Katharine ;

Goodman, Steven ;

Li, Meng ;

Thornton, Katherine ;

Agrawal, Nishant ;

Sokoll, Lori ;

Szabo, Steve A. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Diaz, Luis A., Jr. .

NATURE MEDICINE, 2008, 14 (09) :985-990

[40] Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients [J].

Dietz, Steffen ;

Schirmer, Uwe ;

Merce, Clementine ;

von Bubnoff, Nikolas ;

Dahl, Edgar ;

Meister, Michael ;

Muley, Thomas ;

Thomas, Michael ;

Sueltmann, Holger .

PLOS ONE, 2016, 11 (08)

← 1 2 3 4 5 6 7 8 9 10 →