DNA repair: How Ku makes ends meet

被引:84
作者
Doherty, AJ
Jackson, SR
机构
[1] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 2XY, England
[2] Univ Cambridge, Campaign Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[3] Univ Cambridge, Dept Zool, Cambridge CB2 1QR, England
关键词
D O I
10.1016/S0960-9822(01)00555-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recently determined crystal structure of the Ku heterodimer, in both DNA-bound and unbound forms, has shed new light on the mechanism by which this protein fulfills its key role in the repair of DNA double-strand breaks.
引用
收藏
页码:R920 / R924
页数:5
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