Acyl thiourea derivatives: A study of crystallographic, bonding, biological and spectral properties

被引：15

作者：

Aguilar, E. Contreras ^{[1
]}

Echeverria, G. A. ^{[2
,3
]}

Piro, O. E. ^{[2
,3
]}

Ulic, S. E. ^{[1
,4
]}

Jios, J. L. ^{[5
]}

Tuttolomondo, M. E. ^{[6
]}

Molina, R. D., I ^{[7
]}

Arena, M. E. ^{[7
]}

机构：

[1] Univ Nacl La Plata, Fac Ciencias Exactas, CONICET, CEQUINOR, Bv 120, RA-1900 La Plata, Buenos Aires, Argentina

[2] Univ Nacl La Plata, Fac Ciencias Exactas, Dept Fis, RA-1900 La Plata, Buenos Aires, Argentina

[3] CCT La Plata, CONICET, IFLP, CC 67, RA-1900 La Plata, Buenos Aires, Argentina

[4] Univ Nacl Lujan, Dept Ciencias Basicas, Rutas 5&7, RA-6700 Lujan, Buenos Aires, Argentina

[5] Univ Nacl La Plata, Fac Ciencias Exactas, Dept Quim, CIC,UNIDAD,PLAPIMU,LASEISIC, Republ Argentina 47 Esq 115, RA-1900 La Plata, Buenos Aires, Argentina

[6] Univ Nacl Tucuman, Fac Bioquim Quim & Farm, Inst Quim Fis, INQUINOA,CONICET, San Lorenzo 456,T4000CAN, San Miguel De Tucuman, Argentina

[7] Univ Nacl Tucuman, CONICET, Inst Biotecnol Farmaceut & Alimentaria, INBIOFAL, San Miguel De Tucuman, Argentina

来源：

CHEMICAL PHYSICS LETTERS | 2019年 / 715卷

关键词：

Acyl thioureas; Crystal structure; Spectroscopic analysis; RAHB model; Biological assays; HYDROGEN-BONDS; CRYSTAL-STRUCTURE; ANTICANCER;

D O I：

10.1016/j.cplett.2018.11.020

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The study of two new acylthiourea derivatives (Ar-CO-NH-CS-NH-R) are focused on the bonding interactions supported by X-ray, NMR, UV-Vis, Raman and IR spectroscopy, and NBO, AIM and Hirshfeld surface analysis. The RAHB model is proposed to explain some structural properties. The molecules are stabilized by intra-molecular NH center dot center dot center dot O bonds arranged in the lattice as centre-symmetric dimers held by inter-molecular NH center dot center dot center dot S bonds. The dimers are linked to each other through NH center dot center dot center dot O bonds giving rise to a chain, ribbon-like structure in the network. In vitro bacterial growth inhibition, biofilm formation, biosensor and biofilm metabolic activity were tested considering the broad bioactivity of acylthioureas.

引用

页码：64 / 71

页数：8

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