Exploring the Role of Ubiquitin-Proteasome System in Parkinson's Disease

被引：34

作者：

Behl, Tapan ^{[1
]}

Kumar, Sachin ^{[1
]}

Althafar, Ziyad M. ^{[2
]}

Sehgal, Aayush ^{[1
]}

Singh, Sukhbir ^{[1
]}

Sharma, Neelam ^{[1
]}

Badavath, Vishnu Nayak ^{[1
]}

Yadav, Shivam ^{[3
]}

Bhatia, Saurabh ^{[4
,5
]}

Al-Harrasi, Ahmed ^{[4
]}

Almoshari, Yosif ^{[6
]}

Almikhlafi, Mohannad A. ^{[7
]}

Bungau, Simona ^{[8
]}

机构：

[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India

[2] Shaqra Univ, Coll Appl Med Sci Alquwayiyah, Dept Med Labs Sci, Riyadh, Saudi Arabia

[3] Yashraj Inst Pharm, Lucknow, Uttar Pradesh, India

[4] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman

[5] Univ Petr & Energy Studies, Sch Hlth Sci, Dehra Dun, Uttarakhand, India

[6] Jazan Univ, Coll Pharm, Dept Pharmaceut, Jazan, Saudi Arabia

[7] Taibha Univ, Coll Pharm, Dept Pharmacol & Toxicol, Madinah, Saudi Arabia

[8] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea, Romania

来源：

MOLECULAR NEUROBIOLOGY | 2022年 / 59卷 / 07期

关键词：

alpha-synuclein; Neurodegeneration; Parkinson's disease; Proteolysis; UPS; ALPHA-SYNUCLEIN; PROTEIN-DEGRADATION; MITOCHONDRIAL DYSFUNCTION; LEWY BODY; DOPAMINERGIC NEURON; THERAPEUTIC TARGET; QUALITY-CONTROL; MODEL; INHIBITION; PATHWAY;

D O I：

10.1007/s12035-022-02851-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Over the last decade, researchers have discovered that a group of apparently unrelated neurodegenerative disorders, such as Parkinson's disease, have remarkable cellular and molecular biology similarities. Protein misfolding and aggregation are involved in all of the neurodegenerative conditions; as a result, inclusion bodies aggregation starts in the cells. Chaperone proteins and ubiquitin (26S proteasome's proteolysis signal), which aid in refolding misfolded proteins, are frequently found in these aggregates. The discovery of disease-causing gene alterations that code for multiple ubiquitin-proteasome pathway proteins in Parkinson's disease has strengthened the relationship between the ubiquitin-proteasome system and neurodegeneration. The specific molecular linkages between these systems and pathogenesis, on the other hand, are unknown and controversial. We outline the current level of knowledge in this article, focusing on important unanswered problems.

引用

页码：4257 / 4273

页数：17

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