Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties

被引：54

作者：

Sanyal, Sohini ^{[1
,2
]}

Egee, Stephane ^{[3
]}

Bouyer, Guillaume ^{[3
]}

Perrot, Sylvie ^{[4
]}

Safeukui, Innocent ^{[4
]}

Bischoff, Emmanuel ^{[5
]}

Buffet, Pierre ^{[6
]}

Deitsch, Kirk W. ^{[1
,2
]}

Mercereau-Puijalon, Odile ^{[4
]}

David, Peter H. ^{[4
]}

Templeton, Thomas J. ^{[1
,2
]}

Lavazec, Catherine ^{[4
,5
]}

机构：

[1] Cornell Univ, Dept Microbiol & Immunol, Weill Cornell Med Coll, New York, NY 10021 USA

[2] Cornell Univ, Weill Grad Sch Med Sci, New York, NY 10021 USA

[3] Univ Paris 06, CNRS, UMR 7150, Paris, France

[4] Inst Pasteur, Unite Immunol Mol Parasites, Dept Parasitol Mycol, CNRS,Unite Researche Associee 2581, Paris, France

[5] Inst Pasteur, Unite Genet & Genom Insectes Vecteurs, Dept Parasitol Mycol, CNRS,URA 3012, Paris, France

[6] Univ Paris 06, INSERM, UMR 945, Paris, France

来源：

BLOOD | 2012年 / 119卷 / 02期

关键词：

RED-BLOOD-CELLS; INFECTED HUMAN ERYTHROCYTES; PFMC-2TM SUPERFAMILIES; PARASITE PROTEINS; MALARIA PARASITES; HOST ERYTHROCYTE; GENE FAMILY; MEMBRANE; EXPRESSION; VIRULENCE;

D O I：

10.1182/blood-2011-08-370734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Infection of erythrocytes with the human malaria parasite, Plasmodium falciparum, results in dramatic changes to the host cell structure and morphology. The predicted functional localization of the STEVOR proteins at the erythrocyte surface suggests that they may be involved in parasite-induced modifications of the erythrocyte membrane during parasite development. To address the biologic function of STEVOR proteins, we subjected a panel of stevor transgenic parasites and wild-type clonal lines exhibiting different expression levels for stevor genes to functional assays exploring parasite-induced modifications of the erythrocyte membrane. Using this approach, we show that stevor expression impacts deformability of the erythrocyte membrane. This process may facilitate parasite sequestration in deep tissue vasculature. (Blood. 2012;119(2):e1-e8)

引用

页码：E1 / E8

页数：8

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