Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study

被引：72

作者：

Dossus, Laure ^{[1
]}

Becker, Susen ^{[1
]}

Rinaldi, Sabina ^{[2
]}

Lukanova, Annekatrin ^{[1
,3
]}

Tjonneland, Anne ^{[4
]}

Olsen, Anja ^{[4
]}

Overvad, Kim ^{[5
]}

Chabbert-Buffet, Nathalie ^{[6
,7
]}

Boutron-Ruault, Marie-Christine ^{[8
]}

Clavel-Chapelon, Francoise ^{[8
]}

Teucher, Birgit ^{[1
]}

Chang-Claude, Jenny ^{[1
]}

Pischon, Tobias ^{[9
]}

Boeing, Heiner ^{[9
]}

Trichopoulou, Antonia ^{[10
,11
]}

Benetou, Vasiliki ^{[10
]}

Valanou, Elisavet ^{[10
,11
]}

Palli, Domenico ^{[12
]}

Sieri, Sabina ^{[13
]}

Tumino, Rosario ^{[14
,15
]}

Sacerdote, Carlotta ^{[16
]}

Galasso, Rocco ^{[17
]}

Redondo, Maria-Luisa ^{[18
]}

Bonet Bonet, Catalina ^{[19
]}

Molina-Montes, Esther ^{[20
,21
]}

Altzibar, Jone M. ^{[21
,22
]}

Chirlaque, Maria-Dolores ^{[21
,23
]}

Ardanaz, Eva ^{[21
,24
]}

Bueno-de-Mesquita, H. Bas ^{[25
]}

van Duijnhoven, Franzel J. B. ^{[25
]}

Peeters, Petra H. M. ^{[26
]}

Onland-Moret, N. Charlotte ^{[26
]}

Lundin, Eva ^{[27
]}

Idahl, Annika ^{[28
]}

Khaw, Kay-Tee ^{[29
]}

Wareham, Nicholas ^{[30
]}

Allen, Naomi ^{[31
]}

Romieu, Isabelle

Fedirko, Veronika

Hainaut, Pierre ^{[32
]}

Romaguera, Dora ^{[32
]}

Norat, Teresa ^{[32
]}

Riboli, Elio ^{[32
]}

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Int Agcy Res Canc, Sect Nutr & Metab, F-69372 Lyon, France

[3] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA

[4] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[5] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[6] Hosp Tenon, APHP, Dept Obstet & Gynecol, Paris, France

[7] UPMC, Paris, France

[8] Paris S Univ, Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, INSERM, Villejuif, France

[9] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[10] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[11] Hellen Hlth Fdn, Athens, Greece

[12] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[13] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

[14] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[15] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[16] Ctr Canc Prevent CPO Piedmont, Turin, Italy

[17] CROOB, IRCCS, Rionero In Vulture, PZ, Italy

[18] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[19] Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[20] Andalusian Sch Publ Hlth, Granada, Spain

[21] CIBERESP, Madrid, Spain

[22] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[23] Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[24] Publ Hlth Inst Navarra, Pamplona, Spain

[25] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[26] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[27] Umea Univ, Dept Med Biosci, Umea, Sweden

[28] Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden

[29] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[30] MRC Epidemiol Unit, Cambridge, England

[31] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[32] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2011年 / 129卷 / 08期

基金：

英国医学研究理事会;

关键词：

tumor necrosis factor (TNF)-alpha; soluble TNF receptors; inflammation; endometrial cancer; prospective; FACTOR-ALPHA; INFLAMMATORY CYTOKINES; SERUM-LEVELS; EXPRESSION; HORMONES; OBESITY; CELLS; WOMEN;

D O I：

10.1002/ijc.25840

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-alpha (TNF-alpha), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-alpha and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-alpha (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, P-trend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, P-trend = 0.07) and sTNFR2 (OR: 1.53, 95% CI: 0.92-2.55, P-trend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-alpha and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.

引用

页码：2032 / 2037

页数：6

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