Alphaherpesviruses and the Cytoskeleton in Neuronal Infections

被引:30
|
作者
Zaichick, Sofia V. [1 ]
Bohannon, Kevin P. [1 ]
Smith, Gregory A. [1 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
来源
VIRUSES-BASEL | 2011年 / 3卷 / 07期
关键词
alphaherpesvirus; cytoskeleton; virus transport; neuroinvasion; HERPES-SIMPLEX-VIRUS; US3; PROTEIN-KINASE; AUJESZKYS-DISEASE VIRUS; VARICELLA-ZOSTER-VIRUS; PSEUDORABIES VIRUS; TEGUMENT PROTEIN; GENE-PRODUCT; CAPSID PROTEIN; CYTOPLASMIC DYNEIN; INTERCELLULAR TRAFFICKING;
D O I
10.3390/v3070941
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.
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页码:941 / 981
页数:41
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