Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation

被引：96

作者：

Kang, Min-Sook ^{[1
]}

Hirai, Shizuka ^{[1
]}

Goto, Tsuyoshi ^{[1
]}

Kuroyanagi, Kayo ^{[1
]}

Lee, Joo-Young ^{[1
]}

Uemura, Taku ^{[1
]}

Ezaki, Yoichiro ^{[2
]}

Takahashi, Nobuyuki ^{[1
]}

Kawada, Teruo ^{[1
]}

机构：

[1] Kyoto Univ, Lab Mol Funct Food, Div Food Sci & Biotechnol, Grad Sch Agr, Kyoto 6110011, Japan

[2] Arakawa Chem Ind Ltd, Tsukuba, Ibaraki 3002611, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 369卷 / 02期

关键词：

dehydroabietic acid; inflammation; MCP-1; TNF-alpha; NO; PPAR alpha/gamma; macrophage; coculture; metabolic syndrome;

D O I：

10.1016/j.bbrc.2008.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPAR alpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：333 / 338

页数：6

共 24 条

[1] IMPACT OF LEMONGRASS OIL, AN ESSENTIAL OIL, ON SERUM-CHOLESTEROL [J].

ELSON, CE ;

UNDERBAKKE, GL ;

HANSON, P ;

SHRAGO, E ;

WAINBERG, RH ;

QURESHI, AA .

LIPIDS, 1989, 24 (08) :677-679

[2] Tesaglitazar, a novel dual peroxisome proliferator-activated receptor α/γ agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population [J].

Fagerberg, B ;

Edwards, S ;

Halmos, T ;

Lopatynski, J ;

Schuster, H ;

Stender, S ;

Stoa-Birketvedt, G ;

Tonstad, S ;

Halldórsdóttir, S ;

Gause-Nilsson, I .

DIABETOLOGIA, 2005, 48 (09) :1716-1725

[3] Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea [J].

Fernández, MA ;

Tornos, MP ;

García, MD ;

de las Heras, B ;

Villar, AM ;

Sáenz, MT .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2001, 53 (06) :867-872

[4] Insulin resistance and chronic cardiovascular inflammatory syndrome [J].

Fernández-Real, JM ;

Ricart, W .

ENDOCRINE REVIEWS, 2003, 24 (03) :278-301

[5] Inflammation, dyslipidaemia, diabetes and PPARs:: pharmacological interest of dual PPARα and PPARγ agonists [J].

Gervois, P ;

Fruchart, JC ;

Staels, B .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2004, 58 :22-29

[6] Peroxisome proliferator-activated receptor δ (PPhRδ)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling [J].

Hansen, JB ;

Zhang, HB ;

Rasmussen, TH ;

Petersen, RK ;

Flindt, EN ;

Kristiansen, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (05) :3175-3182

[7] Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor a in HepG2 cells [J].

Hsu, MH ;

Savas, V ;

Griffin, KJ ;

Johnson, EF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (30) :27950-27958

[8] PPAR-γ agonists inhibit production of monocyte inflammatory cytokines [J].

Jiang, CY ;

Ting, AT ;

Seed, B .

NATURE, 1998, 391 (6662) :82-86

[9] Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages [J].

Kang, Ji-Hye ;

Kim, Chu-Sook ;

Han, In-Seob ;

Kawada, Teruo ;

Yu, Rina .

FEBS LETTERS, 2007, 581 (23) :4389-4396

[10] Roles of PPARs in health and disease [J].

Kersten, S ;

Desvergne, B ;

Wahli, W .

NATURE, 2000, 405 (6785) :421-424

← 1 2 3 →