The ESCRT Pathway

被引：1191

作者：

Henne, William M. ^{[1
,2
]}

Buchkovich, Nicholas J. ^{[1
,2
]}

Emr, Scott D. ^{[1
,2
]}

机构：

[1] Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

DEVELOPMENTAL CELL | 2011年 / 21卷 / 01期

关键词：

RECEPTOR DOWN-REGULATION; DOA4 DEUBIQUITINATING ENZYME; MULTIVESICULAR BODY PATHWAY; UBIQUITIN-INTERACTING MOTIF; ENDOSOME-ASSOCIATED COMPLEX; MEMBRANE CURVATURE; SORTING COMPLEX; SACCHAROMYCES-CEREVISIAE; STRUCTURAL BASIS; ENDOPLASMIC-RETICULUM;

D O I：

10.1016/j.devcel.2011.05.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding.

引用

页码：77 / 91

页数：15

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