Asymmetric conjugate addition to alkylidene malonates

被引：64
作者：
Alexakis, A [1 ]
Benhaim, C [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 08期
关键词：
D O I：
10.1016/S0957-4166(01)00196-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Dialkylzinc and trialkylaluminium reagents undergo conjugate addition to alkylidene malonates with 0.5% copper triflate as catalyst. The reaction could be made enantioselective by completing the reaction in the presence of 0.5-1.0 mol% of chiral phosphorus ligand. Enantiomeric excesses (e.e.s) of up to 73% could br attained with a ligand prepared from TADDOL and 2-naphthylcyclohexanol. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1151 / 1157
页数：7
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