Sulfonic acid-functionalized Wang resin (Wang-OSO3H) as polymeric acidic catalyst for the ecofriendly multicomponent synthesis of polyhydroquinolines via Hantzsch condensation

被引：4

作者：

Rao, A. V. Dhanunjaya ^{[1
,2
]}

Surasani, Rajendra ^{[1
]}

Vykunteswararao, B. P. ^{[1
]}

Bhaskarkumar, T. ^{[1
]}

Srikanth, B. ^{[1
]}

Jogdand, Nivrutti R. ^{[1
]}

Kalita, Dipak ^{[1
]}

Lilakar, Jaydeep Kumar D. ^{[3
]}

Siddaiah, Vidavalur ^{[2
]}

Sanasi, Paul Douglas ^{[4
]}

Raghunadh, Akula ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Technol Dev Ctr, Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India

[2] Andhra Univ, Dept Organ Chem Foods Drugs & Water, Visakhapatnam, Andhra Pradesh, India

[3] Dr Reddys Labs Ltd, Res & Dev, Hyderabad, Andhra Pradesh, India

[4] Andhra Univ, Dept Chem Engn, Coll Engn, Visakhapatnam, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 18期

关键词：

Green chemistry; Hantzsch condensation; polyhydroquinoline derivatives; reusable catalyst; Wang-OSO3H; water; ONE-POT SYNTHESIS; ONE-STEP SYNTHESIS; SOLVENT-FREE; EFFICIENT SYNTHESIS; HETEROGENEOUS CATALYST; CALCIUM-ANTAGONISTS; ROOM-TEMPERATURE; DERIVATIVES; 1,4-DIHYDROPYRIDINES; 4-COMPONENT;

D O I：

10.1080/00397911.2016.1213850

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and green approach has been developed for the synthesis of polyhydroquinoline derivatives via Hantzsch condensation reaction directly from corresponding substituted aromatic and aliphatic aldehydes, -keto compounds, active methylene compounds, and ammonium chloride using recyclable polymer-supported sulfonic acid catalyst under aqueous conditions. Environmental acceptability, operational simplicity, low cost, excellent functional group compatibility, and high yields are the important features of this protocol.

引用

页码：1519 / 1528

页数：10

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