An Adjustable Multi-Scale Single Beam Acoustic Tweezers Based on Ultrahigh Frequency Ultrasonic Transducer

被引:29
作者
Chen, Xiaoyang [1 ,2 ]
Lam, Kwok Ho [3 ]
Chen, Ruimin [4 ,5 ]
Chen, Zeyu [4 ,5 ]
Yu, Ping [2 ]
Chen, Zhongping [1 ]
Shung, K. Kirk [4 ,5 ]
Zhou, Qifa [4 ,5 ,6 ]
机构
[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Dept Biomed Engn, Irvine, CA 92715 USA
[2] Sichuan Univ, Coll Mat Sci & Engn, Chengdu, Sichuan, Peoples R China
[3] Hong Kong Polytech Univ, Dept Elect Engn, Kowloon, Hong Kong, Peoples R China
[4] Univ Southern Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA
[5] Univ Southern Calif, NIH Transducer Resource Ctr, Los Angeles, CA 90089 USA
[6] Univ Southern Calif, Dept Ophthalmol, Los Angeles, CA 90089 USA
基金
美国国家卫生研究院;
关键词
acoustic trapping; ultrahigh frequency ultrasonic transducer; adjustable multi-scale tweezers; microparticle trapping and manipulation; piezoelectric actuator" model; BIOMEDICAL APPLICATIONS; OPTICAL TWEEZERS; RADIATION FORCE; MANIPULATION; CELLS; FEASIBILITY; MICROBEAM; SPHERE; WAVES;
D O I
10.1002/bit.26365
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This paper reports the fabrication, characterization, and microparticle manipulation capability of an adjustable multi-scale single beam acoustic tweezers (SBAT) that is capable of flexibly changing the size of tweezers like ordinary metal tweezers with a single-element ultrahigh frequency (UHF) ultrasonic transducer. The measured resonant frequency of the developed transducer at 526MHz is the highest frequency of piezoelectric single crystal based ultrasonic transducers ever reported. This focused UHF ultrasonic transducer exhibits a wide bandwidth (95.5% at -10dB) due to high attenuation of high-frequency ultrasound wave, which allows the SBAT effectively excite with a wide range of excitation frequency from 150 to 400MHz by using the piezoelectric actuator model. Through controlling the excitation frequency, the wavelength of ultrasound emitted from the SBAT can be changed to selectively manipulate a single microparticle of different sizes (3-100m) by using only one transducer. This concept of flexibly changing tweezers size is firstly introduced into the study of SBAT. At the same time, it was found that this incident ultrasound wavelength play an important role in lateral trapping and manipulation for microparticle of different sizes. (C) 2017 Wiley Periodicals, Inc.
引用
收藏
页码:2637 / 2647
页数:11
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