Effects of diamond-like carbon thin film and wrinkle microstructure on cell proliferation

被引：15
作者：
Ban, Masahito [1 ,2 ]
Tobe, Satoshi [1 ]
Takeuchi, Louie [2 ]
机构：
[1] Nippon Inst Technol, Dept Innovat Syst Engn, Minami Ku, 4-1 Gakuendai, Miyashiro, Saitama 3458501, Japan
[2] Nippon Inst Technol, Environm Symbiot Syst Major, Minami Ku, 4-1 Gakuendai, Miyashiro, Saitama 3458501, Japan
来源：
DIAMOND AND RELATED MATERIALS | 2018年 / 90卷
基金：
日本学术振兴会;
关键词：
Diamond-like carbon; Wrinkle microstructure; Cell proliferation; PDMS; COATINGS;
D O I：
10.1016/j.diamond.2018.10.021
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
This paper aims to clarify the effects of diamond-like carbon (DLC) thin film and the wrinkle microstructure formed by depositing the DLC thin film on a poly(dimethylsiloxane) (PDMS) substrate on cell proliferation with a view to applying to cell scaffolds, which are essential technologies to control cellular activity and behaviors for cell therapy and therapeutic applications. Mouse myoblast cell (C2C12) culture tests using substrates with/without the DLC thin film and the wrinkle microstructure revealed that the cell proliferation was largely enhanced by the existence of the DLC thin film on the substrate. Moreover, it was examined how the size of the wrinkle of the DLC thin film deposited PDMS substrates affected cellular growth, and it was found that the wrinkle microstructure had the optimum range of the height difference of the wrinkle, from 0.7 to 1.0 mu m as the surface roughness (Re), for promoting cell proliferation.
引用
收藏
页码：194 / 201
页数：8
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